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Lab Manual for UCSF Clinical Laboratories

Lab Manual for SFGH

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Item Value
Available Stat? Yes
Test code CK
Performed by? Chemistry
Sendout? no
Price range $$
In House Availability Routine: 7 days; STAT: 24 hours/ 7 days
Principle Creatine phosphate and ADP react with serum CK to form ATP which is coupled to the hexokinase-GPD reaction, generating NADPH. The rate of increase in absorbance at 340 nm is proportional to CK activity.
Interpretation CK rises within 6-12 hours following an MI and peaks in 24 hours. CK isoenzymes of cord blood, combined with quantitation of the BB bands, give an excellent prediction of subsequent neurological deficits in children with asphyxia neonatorum.1

1. Major increases: severe myocarditis, progressive muscular dystrophy2, polymyositis and dermatomyositis, alcoholic myopathy, post-seizures, muscle injury secondary to trauma, crush, or gunshot wounds; also increased after exercise and after surgery. Increased during last 2 weeks of pregnancy and post-partum.

Note: Elevated CK in amniotic fluid indicates fetal death3.

2. Mild increases: acute psychosis4, IM injections, electrical cardiac defibrillation, patients in remission with malignant hyperthermia.

3. Normal: Angina pectoris, pericarditis, pulmonary infarction.
Container type gel tube (gold or green top)
Amount to Collect 2 mL
Sample type Blood
Normal range CK (U/liter). The laboratory assays CK at 37°C.

> 16 yrs
Males 38-174 U/L
Females 26-140 U/L
Stability 24 hours at 2-8°C
30 days at -20°C
Interferences 1. See Reference 7.
References 1. Bayer(TM) Clinical Methods CK NAC (49) B01-4137-01 Advia 1650 Operator's Guide. PN 073-5001-09. Last accessed June 2003. Siemens Medical Solutions Diagnostics, Malvern, PA.

2. Kerenyi, T.: Diagnosis of fetal in utero by elevated amniotic fluid CPK levels. Obstet Gyn, 44(2):215,1974.

3. Meltzer, H.: Muscle enzyme release on the acute psychoses. Arch Gen Psychiat, 21:102, 1969.

4. Menzel, Von K.: Kinderarztliche Praxis. pp 413-417, 1974.

5. Rosalki, S.B: An improved procedure for serum creatine kinase determination. J Lab Clin Med, 60:695, 1967.

6. Takahashi, K.: Response of serum CPK to steroid hormone. Arch Neurol, 32:89, 1975.

7. Young DS. Effects of Drugs on Clinical Laboratory Tests ed. 4. Washington D.C.: AACC Press; 1995.

8. Tietz, N.W. Textbook of Clinical Chemistry and Molecular Diagnosis, ed. 4. St. Louis, MO: Elsevier Saunders, 598-601; 2006.
CPT coding 82550
Last Updated 10/24/2012 11:16:08 AM
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