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Lab Manual for UCSF Clinical Laboratories

Lab Manual for SFGH

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Item Value
Available Stat? No
Test code UALB (normalized), UAB
Performed by? Chemistry
Sendout? no
Price range $$
In House Availability 7 days
Principle The microalbumin method is a PEG enhanced immunoturbidimetric assay. Sample containing human albumin is suitably diluted and then reacted with specific antiserum to form a precipitate that can be measured turbidimetrically at 340 nm. The albumin excretion is normalized for creatinine excretion, correcting for diurnal variation in urine excretion.
Interpretation The detection of increasing amounts of low levels of urinary albumin (microalbuminuria) can be used to predict the onset of potentially reversible nephropathy in diabetic patients and in pregnancy-induced hypertension. The measurement of microalbuminuria is also a tool in determining the prognosis of diabetic patients, and therefore in the management of diabetic renal diseases.
Amount to Collect 5 mL
Collection Instructions spot collection.
Sample type Urine
Normal range Urinary Albumin: Spot collection

Urinary albumin (UAB): < or = 10 mg/L
Urinary albumin/creatinine
< 30 mg/g creatinine < 3.39 mg/mmol creatinine
Microalbuminuria: 30-299 mg/g
3.39-33.79 mg/mmol
Nephropathy: > 300 mg/g
> 33.90 mg/mmol

Synonyms Urinary Albumin;
Stability 72 hrs at 2-8°C
References 1. Bakker AJ, Detection of microalbuminuria: Receiver operating characteristic curve analysis favors albumin-to-creatinine ratio over albumin concentration, Diabetes Care, 1999, 22:307-313.

2. Bennett, P.H. et al. Screening and Management of Microalbuminuria in Patients with Diabetes Mellitus: Recommendations to the Scientific Advisory Board of the National Kidney Foundation from an Ad Hoc Committee of the Council on diabetes Mellitus of the National Kidney Foundation. Am J. Kid. Dis. 1995, 25 (1) 107-112.

3. Gatling, W., Rowe, D.J.F., Hill, R.D.: Microalbuminuria: an appraisal of assay techniques and urine collection procedures for measuring urinary albumin at low concentration. In Mothrndrn, V.R. (ed.) The Kidney & Hypertension in Diabetes mellitus. Martinus Nijhoff, Boston 1988, pp 41-50.

4. Kearney, E.M., et al.: Simple immunoturbidimetric method for determining urinary albumin at low concentrations using Cobas-Bio Centrifugal Analyzer. Clin. Pathol. 1987, 40(4): 465-468.

5. Rowe, DJF, Dawnay A, Watts GF. Microalbuminuria in diabetes mellitus: review and recommendations for the measurement of albumin in urine. Ann. Clin. Biochem. 1990; 27:297-312.

6. Sacks et al., Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus, Clin Chem 48:3; 436-472, 2002.
CPT coding 82043
Last Updated 10/22/2012 7:14:09 PM
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