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Lab Manual for UCSF Clinical Laboratories

Lab Manual for SFGH

Internal Resources


Item Value
Available Stat? No
Test code HCV
Performed by? Chemistry
Sendout? no
Price range $$$
In House Availability Daily, Mon - Fri
Principle Microparticle Chemiluminometric Immunoassay.
Interpretation To detect exposure to Hepatitis C Virus. This assay has reduced the incidence of post transfusion hepatitis caused by the Hepatitis C Virus when used to screen donors.

Anti-HCV antibody results are reported from the SFGH Clinical Laboratory, beginning April 1, 2004, as Negative, Presumptive Positive, or Positive. The result is based on the signal-to-cutoff ratio (S/CO) reported by the instrument as recommended in the recently released CDC guidelines (MMWR 52 [No. RR-3] 2003). These guidelines address concerns about false positive Hepatitis C antibody results in certain patient populations with a low prevalence of HCV infection.

For Presumptive Positive results - confirmatory testing with an assay for HCV RNA may be indicated. In one study, only 7% of patients with presumptive positive results were also positive for HCV RNA. A positive antibody result with a negative HCV RNA could indicate past infection with viral clearance or a false positive antibody test. Approval of the Microbiology Laboratory Medicine Resident (206-5699 or pager 415-443-1438) is required for confirmatory testing. For more information please call Dr. Barbara Haller (206-3595) or the Microbiology Laboratory Medicine Resident.
Container type gold top gel tube
Amount to Collect 2 mL
Sample type Blood
Normal range negative
Synonyms HCV;
Stability 2 days at 2-8°C.
References 1. Advia Centaur Assay Manual, Siemens Medical Solutions Diagnostics, Malvern, PA. Pub# 07063235, Rev. C, 2005-01.

2. McHutchison, J.G., Person, J.L., et al. Improved Detection of Hepatitis C Virus Antibodies in High Risk Populations. Hepatology 15:19-25 (1992).

3. Choo. Q.-L., Weiner, A.J., Overby, L.R., Kuo, G., Houghton, M. Hepatitis C Virus: the major causative agent of Viral non-A, non-B Hepatitis, Br. Med. Bull. 46:423-41 (1990).
CPT coding 86803
Last Updated 4/30/2011 10:47:16 AM
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