Opiate drugs of abuse test

The opiate drugs of abuse test is a presumptive screen for possible heroin or morphine abuse within the past 1-2 days and may also detect morphine from the metabolism of codeine.Not definitive or for medicolegal use. To verify a positive result,GC/MS testing for opiate confirmation can be ordered.NOTE -this screening assay is not sensitive for detecting most prescribed opiates such as hydrocodone, oxycodone, codeine itself, etc (see Tables). If detection of a specific opiate is desired, individual assays for the drug of interest can be ordered.

SPECIFICITY

Commonly used opiates and metabolites were tested to determine the cross-reactivity profile for the Opiates assay. Tables 1 and 2 below list the compounds, test concentrations and results. Concentrations selected for testing represent levels that could be observed when the compound is taken at therapeutic (Table 1)and overdose (Table 2)concentrations. Results were evaluated using the assay threshold SAMHSA cutoff for a positive test (2000 ng/mL). Table 1 demonstrates thatbasedon the representative therapeutic levels, none of the assessed opiates or metabolites were above assay threshold. Table 2 shows values representing overdose levels as well as the results obtained for each compound.

*The concentration tested resulted in values below but approaching the cutoff of 2000 ng/mL.

Reference:Abbott Axsym Opiates package insertMay, 2006

Cross-reactivity was also tested for compounds that have similar chemical structure or are used concurrently (Table 3). The compounds listed in Table 3 showed negative assay results well below the threshold of 2000 ng/mL/.