Item Value
Test name Pteridine Profile
Available Stat? No
Turn around times Test performed Monday-Friday. Turnaround time: 3-4 days
Performed by Los Angeles Children's Hospital
Normal range Normals:

Age Biopterin Neopterin %Biopterin mmol/mol creat mmol/mol creat
0-2 months 0.46-1.17 1.02-4.46 20-41
4 months -13 years 0.78-2.68 0.40-1.33 49-74

Dihydropteridine Reductase activity (nmol/min/spot) 1.96-7.51


Age Biopterin Neopterin %Biopterin mmol/mol creat mmol/mol creat
0-4 months 2.03-10.3 2.06-15.5 19-65
8 months -18 years 0.85-4.23 0.31-1.59 60-83

From: Nederwieser A et al. 1980. Acta Helv Paediat. 25;335 and Blau, N. 1988. Ann REv Nutr. 8;185
Container type Urine cup without preservatives (on ice)
Amount to Collect 10 mL blood
Collection Instructions Specimens for this assay should be obtained when PKU is first suspected and before dietary restrictions are instituted.

Do NOT collect urine within 24 hours of a patient having been given a contrast agent for a radiologic study; contrast agents yield unreliable analytical results.

Shield samples from light during and after collection by wrapping the collection container in aluminum foil. Place aluminum foil over the collection bag for bagged patients. Promptly place urine specimens on ice after collection.

Filter paper circles should be completely filled with blood, soaking through from one side to the other. DO NOTE TOUCH ANY OF THE FILTER PAPER CIRCLES BEFORE OR AFTER COLLECTION. Dry the blood spots at room temperature for 2-4 hours while the paper is in a horizontal position. Cover the blood spots with the end flap of the collection device only after the specimen is completely dry.
Sample type Random urine AND blood spots

If you have additional questions regarding this test, please call: 415-353-1667