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Valproic acid

Item Value
Test Update Information Valproic assay changed from the Abbott Axsym method to the Beckman DxC method on 09/20/2012.
Approval req'd? No
Available Stat? Yes
Test code VALP
Performed by Parnassus Chemistry
In House Availability Test available 24 hours per day 7 days per week
Method Turbidimetric inhibition immunoassay (Beckman DxC800)
Collection Instructions Time to steady state: 2-3 days.

Collect trough samples 30 minutes before next dose.
Container type Gold top or Light Green top
Amount to Collect 1 mL blood
Sample type Serum or plasma
Preferred volume 0.5 mL serum or plasma
Min. Volume 0.2 mL serum or plasma
Units mg/L
Normal range
Therapeutic 50-125 mg/L


VPA therapeutic range of 50 - 125 mg/L was set based on recommendations in the literature and consultations with UCSF pharmacists and neurologists.
Source: Valproate: Drug information copyright 1978-2012, Lexicomp, Inc. Accessed at UpToDate www.uptodate.com August 2012.
Critical value > 150 mg/L
Synonyms Depakene; Valproate; Depakote
Stability Room temperature 8 hours, refrigerated 2 days, frozen at -20C 1 week
Turn around times Stat 1 hour, Routine 4 hours
Additional information Click here for A guide on Drug Level Monitoring
LOINC code 4086-5
Last Updated 1/23/2013 3:52:50 PM
Entry Number 973
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