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If you have additional questions regarding this test, please call: 415-353-1667
|Test Update Information||Effective April 19, 2016, tobramycin testing is now being performed on the Beckman DxC 800 instrument. Results run approximately 10% higher on this platform.|
|Test code||TOBPK (Peak), TOBTH (Trough), TOBRN (Random)|
|Performed by||Parnassus Chemistry|
|In House Availability||24 hours per day and 7 days per week|
|Method||Particle enhanced turbidimetric inhibition immunoassay (Beckman DxC 800)|
|Collection Instructions||Time to Steady State: 2-3 doses (1 dose for ICN extended interval dosing).
Collect trough samples 30 minutes prior to 3rd or 4th dose.
For patients on hemodialysis collect just prior to and/or 1 hour post dialysis
For standard dosing draw peak samples 30 minutes after the end of infusion. For ICN extended interval dosing draw peak 30 minutes after end of 4th dose
Note the exact time of collection on BOTH the sample and in Apex (or on any paper orders).
Bring to lab immediately for processing if patient also receiving carbenicillin or other high dose penicillin or cephalosporin because prolonged interactions with these drugs (8 hours or more) at room temperature can modify amino groups and interfere with aminoglycoside assay.
|Container type||Gold top or Light Green top|
|Amount to Collect||1 mL blood|
|Sample type||Serum or plasma|
|Preferred volume||0.5 mL serum or plasma|
|Min. Volume||0.2 mL serum or plasma|
|UCSF Rejection Criteria||Collection time not indicated on sample|
|Processing notes||Mission Bay and Mount Zion: Refrigerate serum or plasma and send to Parnassus Chemistry|
Source of reference range: UCSF/SFGH/VASF joint guidelines for antimicrobial use in adults.
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|Stability||Separate serum or plasma from cells within 2 hours of collection
Separated serum or plasma is stable at room temperature for 8 hours.
Refrigerated samples are stable 48 hours
|Turn around times||1 day|
|Additional information||For desired peak and trough levels in special situations, Click here
Toxicity associated with trough levels > 2 mg/L or peak levels > 10-12 mg/L
Click here for: A Guide on Drug Level Monitoring
|Last Updated||4/21/2016 5:19:46 PM|
|Lab Procedure Link||Click here for procedure|