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|Test code||TOBPK (Peak), TOBTH (Trough), TOBRN (Random)|
|Performed by||China Basin Chemistry|
|In House Availability||Daily (day shift)|
|Method||Competitive chemiluminescent immunoassay (Siemens Centaur)|
|Collection Instructions||Time to Steady State: 2-3 doses (1 dose for ICN extended interval dosing).
Time to Steady State: 2-3 doses (1 dose for ICN extended interval dosing).
Collect trough samples 30 minutes prior to 3rd or 4th dose.
For patients on hemodialysis collect just prior to and/or 1 hour post dialysis
For standard dosing draw peak samples 30 minutes after the end of infusion. For ICN extended interval dosing draw peak 30 minutes after end of 4th dose
Note the exact time of collection on BOTH the sample and the requisition.
Bring to lab immediately for processing if patient also receiving carbenicillin or other high dose penicillin or cephalosporin because prolonged interactions with these drugs (8 hours or more) at room temperature can modify amino groups and interfere with aminoglycoside assay.
|Container type||Gold top or Light Green top|
|Amount to Collect||1 mL blood|
|Sample type||Serum or plasma|
|Preferred volume||0.5 mL serum or plasma|
|Min. Volume||0.2 mL serum or plasma|
|UCSF Rejection Criteria||Collection time not indicated on sample|
|Processing notes||Freeze promptly at ≤ 70C in plastic tube.|
Source of reference range: UCSF/SFGH/VASF joint guidelines for antimicrobial use in adults.
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|Turn around times||1 day|
|Additional information||For desired peak and trough levels in special situations, Click here
Toxicity associated with trough levels > 2 mg/L or peak levels > 10-12 mg/L
Click here for A guide on Drug Level Monitoring
|Last Updated||1/23/2013 3:24:58 PM|
|Lab Procedure Link||Click here for procedure|
If you have additional questions regarding this test, please call: 415-353-1667