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Tissue Transglutaminase Antibody, IgA

Item Value
Approval req'd? No
Available Stat? No
Test code TTGT
Performed by Immunology
In House Availability Tuesday (day shift)
Method Chemiluminescent
Collection Instructions Avoid hemolysis
Container type Gold top
Amount to Collect 2 mL blood
Sample type Serum
Preferred volume 1 mL serum
Min. Volume 0.5 mL serum
UCSF Rejection Criteria Grossly hemolyzed, lipemic or icteric specimens
Processing notes Freeze serum at -20C.
Units Chemiluminescent Units (CU)
Normal range
Negative < 20 CU
Weak Positive 20 - 30 CU
Positive > 30 CU
Synonyms Celiac disease; endomysial antibody
Turn around times 2-8 days
Additional information This test may be useful in providing serologic support for a diagnosis of gluten-sensitive enteropathy (found in celiac disease and dermatitis herpetiformis). The European Society for Pediatric Gastroenterology and Nutrition (ESPGAN) revised criteria in 1990 for diagnosis of celiac disease in children to include serologic testing for IgA endomysial antibodies.

Tissue transglutaminase has been identified as the primary target for IgA endomysial antibodies. IgA tissue transglutaminase (TTG) antibodies are thought to be equally sensitive for celiac disease in comparison with anti-gliadin antibodies but with increased specificity. Results in the weak positive range are considered equivocal and may be repeated, if clinically indicated. IgA TTG antibodies most often disappear when patients adhere to a gluten-free diet, thus this test may be useful in monitoring patient adherence to diet. Since IgA-deficiency is not uncommon in patients with celiac disease, serum IgA levels may be ordered to confirm a negative result on this test.
CPT coding 83520
LOINC code 31017-7
Last Updated 5/31/2016 9:14:57 PM
Entry Number 927
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