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Tissue Transglutaminase Antibody, IgA
|In House Availability||Friday (day shift)|
|Container type||Gold top|
|Amount to Collect||1 mL blood|
|Preferred volume||0.5 mL serum|
|Min. Volume||0.3 mL serum|
|Processing notes||Freeze serum at -20C.|
See "Additional information"
|Synonyms||Celiac disease; endomysial antibody|
|Turn around times||2-9 days|
|Additional information|| This test may be useful in providing serologic support for a diagnosis of gluten-sensitive enteropathy (found in celiac disease and dermatitis herpetiformis). The European Society for Pediatric Gastroenterology and Nutrition (ESPGAN) revised criteria in 1990 for diagnosis of celiac disease in children to include serologic testing for IgA endomysial antibodies.
Tissue transglutaminase has been identified as the primary target for IgA endomysial antibodies. IgA tissue transglutaminase (TTG) antibodies are thought to be equally sensitive for celiac disease in comparison with anti-gliadin antibodies but with increased specificity. Results in the weak positive range are considered equivocal and may be repeated, if clinically indicated. IgA TTG antibodies most often disappear when patients adhere to a gluten-free diet, thus this test may be useful in monitoring patient adherence to diet. Since IgA-deficiency is not uncommon in patients with celiac disease, serum IgA levels may be ordered to confirm a negative result on this test.
Interpretation of results:
|Last Updated||6/1/2011 11:48:52 AM|