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Thyroid Stimulating Hormone
|Test Update Information||Effective May 1, 2016, TSH testing will be performed on the Abbott Architect i2000 analyzer. TSH values read approximately 10% lower than the prior Beckman DxI method but did not significantly affect the reference range or classification of subjects as normal or abnormal.|
|Clinical Questions||Does my patient have autoimmune thyroiditis?|
|Test group||Thyroid tests|
|Performed by||Chemistry China Basin|
|In House Availability||Test performed Monday-Saturday (day shift)|
|Method||Chemiluminescent Microparticle Immunoassay (Abbott Architect i2000)|
|Container type||Gold top or Light Green top|
|Amount to Collect||1.6 mL blood|
|Sample type||Serum or heparinized plasma|
|Preferred volume||0.6 mL serum or heparinized plasma|
|Min. Volume||0.4 mL serum or heparinized plasma|
2 months to <6 months 0.73-4.77
6 months to <14 years 0.70-4.17
Reference ranges apply to non-pregnant individuals. In pregnant subjects, TSH levels decline in the first trimester and then rise after 10 -12 weeks gestation. The upper reference limit is 2.5 mIU/L in the first trimester, 3.0 in the second trimester, and 3.5 mIU/L in the third trimester. The lower reference limit for TSH in pregnancy is 0.1 – 0.2 mIU/L lower than the range limit in non-pregnant subjects (Garber JR et al. Clinical Practice Guidelines for Hypothyroidism in Adults: American Association of Clinical Endocrinologists and the American Thyroid Association, Thyroid 12:1200-1235, 2012).
Pediatric reference ranges adopted from Pediatric Reference Intervals seventh edition (Soldin, Steven J. et al) and the Canadian Laboratory Initiative on Reference Interval Database (CALIPER) study, Clinical Chemistry September 2013 vol. 59 no. 9 1393-1405.
Neonatal and cord blood levels are 2-4x higher than levels at ≥ 2 weeks of age through adult life. Neonatal levels are also screened by the State program.
Adult reference ranges were adopted from NHANES III and verified in 63 adult blood donors (Hollowell JG et al. Serum TSH, T4, and thyroid antibodies in the United States population ,1988 to 1994: National Health and Nutrition Examination Survey , NHANES III. J Clin Endocrinol Metab 87:489–499, 2002. Garber JR et al. Clinical Practice Guidelines for Hypothyroidism in Adults: American Association of Clinical Endocrinologists and the American Thyroid Association, Thyroid 12:1200-1235, 2012).
|Turn around times||0 -2 days|
|Additional information||According to the assay manufacturer the low end functional sensitivity (20% coefficient of variation cutoff) for this assay is 0.01 mIU/L.|
|Last Updated||5/2/2016 12:25:47 PM|
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