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TRH Stimulation Test

Item Value
Approval req'd? No
Available Stat? No
Test code
Test group Thyroid tests
Performed by China Basin Chemistry
In House Availability Daily (day shift)
Method Post-TRH measurement of TSH
Collection Instructions Collect specimens at 0 and 15 or 30 minutes after giving 500 µg of TRH iv, and submit them for assay of TSH. Be sure to ote the time directly on each of the two samples
Container type Gold top
Amount to Collect 2 mL blood
Sample type Serum
Preferred volume 1 mL serum
Units mIU/L
Normal range TSH 2-4x basal and > 10 mIU/L 15-30 min post-TRH
Synonyms TSH releasing Hormone
Turn around times 1 day
Additional information TRH (Thyroliberin) stimulation is useful only if results of the standard tests (TSH, Free T4) are equivocal. Responses are exaggerated in primary hypothyroidism, decreased in hyperthyroidism (natural or factitious) and in TSH deficiency.

After IV administration of TRH, TSH normally rises 2- to 4-fold over baseline values. In subclinical hyperthyroidism and in hypothyroidism secondary to pituitary failure TSH levels do not rise normally; in primary hypothyroidism the response to TRH is exaggerated. TRH Stimulation was previously helpful when results of the T4 Index and TSH were equivocal, but with the advent of sensitive and accurate assays for TSH and Free T4, it has fallen into disuse.

Also see Prolactin-TRH Stimulation.
Last Updated 6/16/2008 3:03:15 PM
Entry Number 923
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