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Lab Manual for Moffitt-Long and Mount Zion

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Thyroglobulin Antibodies

Item Value
Test Update Information Anti-thyroglobulin antibody assay and reference range changed effective March 19, 2013.
Approval req'd? No
Available Stat? No
Test code TGAB
Test group Thyroid tests
Performed by China Basin Chemistry
In House Availability Tuesday, Friday (day shift)
Method Chemiluminescent Microparticle Immunoassay-Abbott Architect i2000
Container type Gold top
Amount to Collect 2 mL blood
Sample type Serum
Preferred volume 1 mL serum
Min. Volume 0.1 mL serum
Processing notes Freeze serum at -20C.
Units IU/mL
Normal range < 4.11 IU/mL

Reference range was adopted from reagent vendor (Abbott Labs) performed studies and verified in house by running 21 male samples less than 30 years of age with a TSH level between 0.5-2.0 mIU/L. This selection criteria is specified in the NACB: Laboratory Support for the Diagnosis and Monitoring of Thyroid Disease guidelines.
Synonyms anti-Tg antibodies
Turn around times 1-5 days
Additional information This assay is automatically performed and reported whenever a thyroglobulin test is ordered. The presence of anti-thyroglobulin antibodies can variably interfere in thyroglobulin immunoassays and tend to falsely lower thyroglobulin results.

Note: Assays for anti-thyroglobulin antibodies are not well standardized and results with this Abbott Architect assay should not be directly compared with the results of other anti-thyroglobulin antibody assays.
The Architect anti-thyroglobulin assay is more sensitive for detection of anti-TG antibodies than other commonly used anti-TG antibody assays including the Siemens Immulite assay when using cutoffs based on the manufacturer's reference range or even lower cutoffs in some cases (Pickett et al. Annals of Clinical Biochemistry 49:463-467, 2012). The coefficient of variation of this assay is approximately 6% around the manufacturer's normal range cutoff of 4.11 IU/mL. Results below 4.11 are reported as <4.11.
LOINC code 8098-6
Last Updated 6/14/2013 1:32:48 PM
Entry Number 920
Lab Procedure Link Click here for Procedure

If you have additional questions regarding this test, please call: 415-353-1667

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