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|Test Update Information||Anti-thyroglobulin antibody assay and reference range changed effective March 19, 2013.|
|Test group||Thyroid tests|
|Performed by||China Basin Chemistry|
|In House Availability||Tuesday, Friday (day shift)|
|Method||Chemiluminescent Microparticle Immunoassay-Abbott Architect i2000|
|Container type||Gold top|
|Amount to Collect||2 mL blood|
|Preferred volume||1 mL serum|
|Min. Volume||0.1 mL serum|
|Processing notes||Freeze serum at -20C.|
|Normal range||< 4.11 IU/mL
Reference range was adopted from reagent vendor (Abbott Labs) performed studies and verified in house by running 21 male samples less than 30 years of age with a TSH level between 0.5-2.0 mIU/L. This selection criteria is specified in the NACB: Laboratory Support for the Diagnosis and Monitoring of Thyroid Disease guidelines.
|Turn around times||1-5 days|
|Additional information||This assay is automatically performed and reported whenever a thyroglobulin test is ordered. The presence of anti-thyroglobulin antibodies can variably interfere in thyroglobulin immunoassays and tend to falsely lower thyroglobulin results.
Note: Assays for anti-thyroglobulin antibodies are not well standardized and results with this Abbott Architect assay should not be directly compared with the results of other anti-thyroglobulin antibody assays.
The Architect anti-thyroglobulin assay is more sensitive for detection of anti-TG antibodies than other commonly used anti-TG antibody assays including the Siemens Immulite assay when using cutoffs based on the manufacturer's reference range or even lower cutoffs in some cases (Pickett et al. Annals of Clinical Biochemistry 49:463-467, 2012). The coefficient of variation of this assay is approximately 6% around the manufacturer's normal range cutoff of 4.11 IU/mL and approximately 16% at a level of 1.2 IU/mL. Results below 1.2 IU/mL are reported as < 1.2.
|Last Updated||3/19/2013 8:56:34 AM|
If you have additional questions regarding this test, please call: 415-353-1667