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|Approval req'd?||Yes, contact Chemistry/Immunology Resident at x3-1438. for samples from non-pregnant patients.|
|Test group||Thyroid tests|
|Collection Instructions||Indicate testing is for pregnant patient on requisition.|
|Container type||Gold top|
|Amount to Collect||2 mL blood|
|Preferred volume||1 mL serum|
|Min. Volume||0.5 mL serum|
|Processing notes||Store at room temperature. Order Quest # 17733|
|Stability||Room temperature 7 days, refrigerated 7 days, frozen at -20C 1 month.|
|Turn around times||Test run Monday-Friday AM. Results available 1-2 days.|
|Additional information||Conversion: 1 µg/dL = 12.9 nmol/L
Clinical significance: Thyroxine (T4) is the major secretory hormone of the thyroid. Only 0.03% of T4 is unbound and free for exchange with tissues. Thyroid function may be assessed with thyroid stimulating hormone (TSH) and free T4 measured.
Although free T4 is generally preferred over total T4 when monitoring thyroid function, the total T4 measurement may be preferred for monitoring of pregnant patients where total T4 reference ranges are available. The total T4 concentrations tend to be stable throughout pregnancy at 150% of the values in non- pregnant subjects and can be useful when the levels are evaluated according to pregnancy specific total T4 reference ranges which are approx. 1.5 times greater than non-pregnant ranges.
Reference: Mandel SJ, Spencer CA, Hollowell JG., Are detection and treatment of thyroid insufficiency in pregnancy feasible?Thyroid. 2005 Jan;15(1):44-53.
|Last Updated||8/16/2011 10:42:44 AM|