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Lab Manual for Moffitt-Long and Mount Zion

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Salicylate

Item Value
Test Update Information Salicylate assay changed from the Abbott Axsym method to the Beckman DxC method on 6/25/2012.
Approval req'd? No
Available Stat? Yes
Test code SAL
Performed by Parnassus Chemistry
In House Availability Test available 24 hours per day 7 days per week
Method Timed-endpoint using salicylate hydroxylase (Beckman DxC800)
Container type Gold top or Light Green top
Amount to Collect 1 mL blood Click here for Microdetermination info
Sample type Serum or plasma
Preferred volume 0.5 mL serum or plasma
Min. Volume 0.3 mL serum or plasma Click here for Microdetermination info
Units mg/dL
Normal range
Therapeutic 10-30 mg/dL
Critical value > 35 mg/dL
Synonyms ASA; aspirin; acetylsalicyclic acid
Stability Room temperature 8 hours, refrigerated 2 days, frozen 1 week
Turn around times STAT 1 hour, Routine 1-3 days
Additional information Note that the therapeutic range applies to use of aspirin for anti-inflammatory purposes. According to the UpToDate guidelines (accessed May 21, 2012) on "Salicylate poisoning in adults" by Barnett and Boyer, "Therapeutic serum salicylate concentrations fall between 10 to 30 mg/dL (0.7 to 2.2 mmol/L); values above 40 mg/dL are associated with toxicity. Although there is no absolute correlation between plasma salicylate concentration and symptoms, most patients show signs of intoxication when the plasma concentration exceeds 40 to 50 mg/dL. Plasma salicylate concentrations >100 mg/dL in acute intoxication and >60 mg/dL in chronic intoxication are indications for hemodialysis."
LOINC code 4024-6
Last Updated 6/20/2012 1:46:46 PM
Entry Number 841

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