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Lab Manual for Moffitt-Long and Mount Zion

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Plasma Renin Activity

Item Value
Approval req'd? No
Available Stat? No
Test code REN
Performed by Quest
Sendout? Yes
Method LC/MS/MS
Patient Preparation Discontinue diuretics, estrogens and oral contraceptives for at least 2 weeks and non-diuretic antihypertensive Rx several days before study. Dietary sodium content should be maintained for at least 3 days prior to testing.
Collection Instructions Supine specimens should be drawn in the morning, preferably after overnight recumbency but in any case after a minimum of 30 minutes supine prior to drawing the specimen.

Collect in lavender tube and transport to the laboratory at room temp for prompt separation and freezing of plasma. DO NOT place on ice or refrigerate sample.
Container type Lavender top
Amount to Collect 3 mL blood
Sample type EDTA Plasma
Preferred volume 1 mL plasma
Min. Volume 0.5 mL plasma
Processing notes After collection, sample can be stored up to 24 hours at room temperature. DO NOT REFRIGERATE THE SAMPLE. Centrifuge and freeze the plasma in plastic at -20C as soon as possible after receipt.
Ref Lab Rejection Criteria Specimen received thawed, refrigerated samples.
Units ng/mL/hour
Normal range 0.25-5.82 ng/mL/hour

Pediatric ranges have not been established for this assay. Please see 'Additional Information'
Stability Room temperature 24 hours, frozen at -20C 28 days.
Turn around times Test run Tuesday-Saturday. Turnaround time: 1-3 days.
Additional information Refrigeration causes cryoactivation of prorenin to renin causing falsely high renin activity results.
CPT coding 84244-90
LOINC code 2915-7
Last Updated 2/27/2013 10:32:07 AM
Entry Number 817

If you have additional questions regarding this test, please call: 415-353-1667

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