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Protein Electrophoresis, serum

Item Value
Test Update Information Effective 10/20/14, all serum protein electrophoresis requests will be tested by Capillary Electrophoresis.

New reference range change effective 10/20/14.
Approval req'd? No
Available Stat? No
Test code PE
Test group Electrophoresis by Sebia Capillarys 2 Flex
Performed by China Basin Chemistry
In House Availability Monday-Friday (day shift) as needed
Method Electrophoresis
Container type Gold top
Amount to Collect 2 mL blood
Sample type Serum
Preferred volume 1 mL serum
Min. Volume 0.4 mL serum
UCSF Rejection Criteria Plasma sample received
Processing notes Refrigerate serum
Units g/dL
Normal range For patients ≥ 1 year old:
Components Reference Interval
Albumin 3.75 – 5.01 g/dL
Alpha-1 Globulins 0.19 – 0.46 g/dL
Alpha-2 Globulins 0.48 – 1.05 g/dL
Beta Globulins 0.48 – 1.10 g/dL
Gamma 0.62 – 1.51 g/dL


Note: Reference intervals are not available for patients < 1 year old. Results should read lower due to a lower total protein in patients who are < 1 year old.

Reference range adopted from ARUP Laboratory and verified by UCSF Clinical Labs by running 39 outpatient samples with normal ALB, AST, ALT, LD, creat/eGFR, & CRP.
Synonyms SPEP; PEP; paraprotein
Stability Refrigerated 10 days, frozen 1 month
Turn around times 1-3 days
Additional information Total Protein is automatically included in test request.

Most monoclonal cryoglobulins are detected by serum electrophoresis, but if cryoglobulins are suspected and the PEP is normal, order Cryoglobulin, Quantitative. Most monoclonal proteins are also detected by electrophoresis, but if negative in a patient with a high suspicion of a monoclonal gammopathy it may be detectable by immunofixation electrophoresis or by free light chain immunoassay.

An interpretation of this test by a laboratory physician will automatically be performed and billed for separately.
CPT coding 84165
LOINC code 12851-2
Last Updated 9/17/2014 2:54:46 PM
Entry Number 797
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