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Prostate Specific Antigen, Total

Item Value
Test Update Information Total PSA method changed from Siemens Immulite 2000 to the Abbott Architect i2000 on March 25, 2013
Approval req'd? No
Available Stat? No
Test code PSAS, PRSA
Test group PSA
Performed by China Basin Chemistry
In House Availability Monday-Friday (day shift)
Method Chemiluminescent Immunoassay-Abbott Architect i2000
Container type Gold top or Red top
Amount to Collect 1 mL blood
Sample type Serum
Preferred volume 0.5 mL serum
Min. Volume 0.3 mL serum
Processing notes Refrigerate
Units µg/L
Normal range Males 40 years of age and above: <4.00 ug/L.

Vendor reference range verified in-house by running 75 random male samples 40 years of age and older collected from outpatient settings.

See also 'Additional Information'
Synonyms PSA
Turn around times 1-3 days
Additional information The test can detect levels as low as 0.015 µg/L as an index of early recurrence of carcinoma after radical prostatectomy. Lower levels are reported as "< 0.015 µg/L".

PSAS: For annual screening in Medicare patients over age 49. At least 11 months must have elapsed following the month in which the most recent Medicare-covered test was performed. Because the laboratory cannot know with certainty when the most recent test was performed, including testing at other laboratories, the patient will be asked to sign an Advanced Beneficiary Notice or a Hospital Notice of Non-Coverage agreeing to financial liability if payment is refused by Medicare.

PRSA: For screening Non-Medicare patients and monitoring patients after prostatectomy.

The most recent estimates of Prostate cancer probability (JAMA 1997;277:1214 and 1998;279:1542) are:

Total PSA Probability of Cancer
0-2 µg/L 1%
2-4 µg/L 15%
4-10 µg/L 25%
> 10 µg/L > 50%


Percent (%) of apparently healthy patients with PSA valuies at the following levels:
Healthy Subjects (# tested) < 4.0 µg/L 4-10 µg/L 10-30 µg/L 30-60 µg/L > 60 µg/L
Females (296) 100.0 0.0 0.0 0.0 0.0
Males Ages 40 - 49 (99) 100.0 0.0 0.0 0.0 0.0
Males Ages 50 - 59 (120) 97.5 2.5 0.0 0.0 0.0
Males Ages 60 - 69(123) 93.5 6.5 0.0 0.0 0.0
Males Ages 70 - 79 (124) 91.9 7.3 0.8 0.0 0.0


In this study, 95.5% of the specimens from apparently healthy male subjects (n=466) had values of 4.0 ng/mL or less.

* from Abbott reagent insert; Values developed for the ARCHITECT i2000 analyzer.
Medical Necessity? Yes. Click here for more information
Last Updated 4/1/2014 11:57:12 AM
Entry Number 787
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