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Plasminogen Activity

Item Value
Approval req'd? Yes, contact Hematology at x3-1747
Available Stat? No
Test code PLMA
Test group Plasminogen
Performed by Quest
Sendout? Yes
Method Spectrophotometric (chromogenic substrate)
Collection Instructions Note the time of draw on requisition.

1. Check the expiration date on the label of the blue top vacutainer before drawing the patient.

2. For blood collection in a sodium citrate blue top, the tube must be filled to above the Minimum Fill Indicator on the tube. It is crucial to wait and allow the tube to stop filling before removing it from the needle.

3. With use of a butterfly needle, draw about 1 cc using a separate blue top to remove air from tubing, discard the first tube and then draw a second blue top tube filled to the full extent of the vacuum.

4. Tubes should not be filled past the Maximum Fill dashed line by either using a syringe or removing the tube cap.
Container type Blue top filled to full extent of vacuum x2
Amount to Collect 5.4 mL blood
Sample type Citrated plasma
Preferred volume 2 mL plasma
Min. Volume 1 mL plasma
UCSF Rejection Criteria Samples collected in outdated blue top vacutainer. Over-filled or under-filled tubes may be rejected Hemolyzed sample.
Processing notes Process immediately and transfer to a plastic tube w/ a plastic pipet. Freeze at -20C. Order Quest # 59709P
Units % activity
Normal range 65-176%
Stability Room temperature unacceptable, refrigerated unacceptable, frozen at -20C 1 month.
Turn around times Test run on Tuesday and Thursday evenings.
Turnaround time: 3-7 days.
Additional information The activated form of plasminogen, plasmin, lyses fibrin clots. Plasminogen activity is increased in pregnancy and as an acute phase reactant. Rare hereditary deficiency of plasminogen predisposes to ligneous conjunctivitis. Low activity is associated with DIC, liver disease, and increased risk of thrombosis.
CPT coding 85420-90
LOINC code 28660-9
Last Updated 10/2/2010 11:52:26 AM
Entry Number 746
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