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Neutrophil Cytoplasmic Antibodies
| Item | Value | ||||||
|---|---|---|---|---|---|---|---|
| Approval req'd? | No | ||||||
| Available Stat? | No | ||||||
| Test code | ANCA | ||||||
| Test group | Neutrophil Antibodies | ||||||
| Performed by | Immunology | ||||||
| In House Availability | Wednesday (day shift) | ||||||
| Method | EIA | ||||||
| Collection Instructions | Avoid hemolysis | ||||||
| Container type | Gold top | ||||||
| Amount to Collect | 2 mL blood | ||||||
| Sample type | Serum | ||||||
| Preferred volume | 1 mL serum | ||||||
| Min. Volume | 0.5 mL serum | ||||||
| UCSF Rejection Criteria | Hemolyzed | ||||||
| Processing notes | Freeze serum at -20°C. | ||||||
| Units | Units | ||||||
| Normal range | Myeloperoxidase Antibody (MPO) and Proteinase-3 Antibody (PR3) :
|
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| Synonyms | ANCA; Anti-Neutrophil Antibodies; anti-MPO; Myeloperoxidase antibodies; anti-myeloperoxidase; Proteinase-3 Antibody; anti-Proteinase-3 Antibody; PR3; anti-PR3; | ||||||
| Turn around times | 2-8 days | ||||||
| Additional information | This test may be useful in discriminating among the various vasculitides. Cytoplasmic (c-ANCA) antibodies giving diffuse cytoplasmic staining are directed against Proteinase-3, and are suggestive of a spectrum of diseases which includes Wegener's Granulomatosis, polyarteritis nodosa, Churg-Strauss syndrome, and primary necrotizing and crescentic glomerulonephritis. Perinuclear (p-ANCA) staining is due to antibodies to myeloperoxidase (MPO) and other antigens such as elastase and lactoferrin, and is less specific. | ||||||
| LOINC code | 45151-8 | ||||||
| Last Updated | 1/30/2013 12:10:33 PM | ||||||
| Entry Number | 684 |
If you have additional questions regarding this test, please call: 415-353-1667