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Neonatal Alloimmune Thrombocytopenia - Parental evaluation

Item Value
Approval req'd? REQUIRES INSURANCE INFORMATION , AUTHORIZATION FROM HEALTH CARE PROVIDER FOR TEST AND PRIOR APPROVAL BEFORE COLLECTION OF SAMPLES.

Contact Blood Bank at x3-1313 to coordinate testing.

Blood Bank will complete the Platelet & Neutrophil Immunology Lab Requisition and order the appropriate test code.
Available Stat? No
Test code MOLT (Order in Apex as 'Miscellaneous Outside Lab Test' using the complete test name above)
Test group Neonatal Alloimmune Thrombocytopenia
Performed by Blood Center of Wisconsin
Sendout? Yes
Method ELISA, Flow cytometry, PCR
Collection Instructions See information under Approval req'd BEFORE submitting samples

Specimens are only accepted 8 AM-5 PM Monday through Thursday and 8 AM-12 Noon on Friday.
Container type
Mother Yellow top (ACD) x3 and Red top x3
Father Yellow top (ACD) x3
Amount to Collect
Mother 25.5 mL blood in Yellow tops (ACD) and 18 mL blood in Red tops
Father 25.5 mL blood in Yellow tops (ACD)
Sample type ACD whole blood AND Serum
Preferred volume
Mother 25.5 mL ACD whole blood and 10 mL serum
Father 25.5 mL ACD whole blood
Min. Volume
Mother 25.5 mL ACD whole blood and 10 mL serum
Father 25.5 mL ACD whole blood
UCSF Rejection Criteria Samples collected outside of stated time frames.
Processing notes Forward all samples unspun to Chnia Basin for FedEx pickup at 4:00 PM Monday - Friday. Mark FedEx shipping form for next day delivery and Mark container prominently with REFRIGERATE UPON ARRIVAL.

Samples must be received within 4 days of collection at Blood Center of Wisconsin.

Ship to: Client Serivces / PNIL. Blood Center of Wisconsin, 638 North 18th Street, Milwaukee, WI 53233-2121 Phone: 800-245-3117, ext. 6250

PLEASE CALL THE LABORATORY (800-245-3117, ext 6255) FOR ADVICE IF YOU WILL SHIP SAMPLES NEAR A MAJOR HOLIDAY.
Ref Lab Rejection Criteria Sample > 4 days old when received
Normal range
Synonyms NAIT; anti-platelet antibodies; platelet specific antibodies; PlA1; Bak; Pen; NAT; NATP; flow cytometry
Turn around times 1-2 weeks
Additional information Mothers with normal platelet counts may deliver a baby with low platelet counts. There is a possibility of neonatal alloimmune thrombocytopenia (NATP) in which the mother lacks a platelet antigen that the baby inherits from the father. A maternal antibody is formed against the father's platelet antigen that crosses the placenta and causes the fetus to be thrombocytopenic.

About 50% of maternal alloimmunization arises due to the mother being among the 2% of the general population whose platelets lack the common PlA1 antigen; another 30% of alloimmunization involves the Bak and Pen antigens (common in Asia), or other antigen
systems.

If evidence of maternal alloimmunization is found, further evaluation may be appropriate to evaluate the risk and permit prophylaxis for neonatal alloimmune thrombocytopenic purpura in future pregnancies.
CPT coding 83891-90 x2, 83900-90 x2, 83901-90 x10, 83912-90 x2, 83896-90 x36, 86022-90 x16
Last Updated 2/20/2014 3:11:13 PM
Entry Number 680
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