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Albumin (Microalbumin), spot urine
|In House Availability||Tuesday, Thursday, Saturday (day shift)|
|Collection Instructions||First A.M. sample preferred for random urine.|
|Container type||Urine cup|
|Amount to Collect||10-20 mL|
|Sample type||Random urine|
|Preferred volume||2 mL urine|
|Min. Volume||0.5 mL urine|
|Processing notes||Aliquot 2 mL, note that sample is a "spot" or random urine sample. Order AUR and CRUR.|
|Normal range|| Random urine:
|Turn around times||1-3 days|
|Additional information||A creatinine is performed on the same sample to calculate the result and will be reported and billed separately.
Diabetes mellitus is one of the commonest causes of end-stage renal disease. The National Kidney Foundation recommends that diabetics > 12 years old be tested yearly for microalbuminuria if the rate of excretion is within normal limits (Amer J Kid Dis. 1995;25:107). The Diabetes Coalition of California recommends annual testing for microalbuminuria beginning 5 years after the diagnosis of type I diabetes mellitus and beginning at diagnosis of type II disease. The cost benefit of these strategies are not established.
Transient increases in urinary albumin excretion are seen with heavy exercise, urinary infection, acute febrile illness, heart failure and following the administration of NSIADs or ACE inhibitors, all of which should be avoided during screening. Because of the difficulty in collecting and accurately timing 24 hour samples, a spot collection is recommended and the albumin excretion is normalized for creatinine excretion, correcting to some extent for the diurnal fluctuation in urinary output. Abnormalities should be verified by a repeatedly positive assay within 6-12 weeks before a diagnosis of diabetic microalbuminuria or diabetic nephropathy is made.
|Last Updated||3/24/2013 7:12:13 PM|