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Lab Manual for Moffitt-Long and Mount Zion

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JC Virus DNA, Quantitative

Item Value
Approval req'd? Yes, for testing on non-plasma samples
Available Stat? No
Test code JCV
Test group JCV
Performed by Viracor
Sendout? Yes
Method Real time PCR
Collection Instructions Fresh tissue specimens must be placed in saline in a red top tube to prevent dehydration
Container type Lavender top preferred.

Gold top, Red top, urine cup, CSF tube or sterile collection tube acceptable with approval.
Amount to Collect 6 mL blood (Lavender top) or 6 mL blood (Gold or Red top), random urine (See preferred volume)
Sample type Preferred sample is EDTA plasma.

Testing may be performed on other sample types: serum, CSF, random urine, fresh or paraffin embedded tissue with approval.
Preferred volume
Plasma 3 mL
CSF 1 mL
Urine 5 mL
Tissue 1mm x 1mm
Min. Volume
Plasma 2 mL
CSF 1 mL
Urine 5 mL
UCSF Rejection Criteria Improperly submitted sample
Processing notes Keep plasma, whole blood and urine specimens at room temperature. Ship at room temperature.

Fresh tissue specimens must be placed in saline to prevent dehydration during shipping.
Ship at room temperature.

Freeze CSF and ship frozen on dry ice.

Send samples to China Basin for Medical Courier pickup at 1600 hours. Monday-Friday.
Units copies/mL
Normal range Not detected
Synonyms JC virus PCR; John Cunningham virus; JVC
Turn around times Test run Monday-Friday. Results Available within 24 hours of specimen receipt at Viracor.
Additional information JCV is the etiologic agent of progressive multifocal leukoencephalopathy (PML) which is mainly seen in HIV patients, organt transplant patients and other immunodeficient syndromes. In addition to PML, JCV also causes nephropathy in the renal transplant setting although with considerably less frequency than BKV.

JCV should always be considered in an immunocompromised patient with progressively deteriorating CNS function. Quantitative JCV DNA PCR can be used to detect JCV in CSF in the setting of CNS disease and blood and urine in the setting of renal dysfunction. The DNA PCR can be used to track the course of the infection as well as monitor response to treatment.

Assay range: 100-1.0x108 copies/mL
LOINC code 49412-0
Last Updated 11/21/2013 12:53:41 PM
Entry Number 579
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