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IgG Index, CSF

Item Value
Approval req'd? No
Available Stat? No
Test code IGGI and IGGIS
Test group IgG
Performed by Immunology
In House Availability Thursday (day shift)
Method Rate nephelometry
Collection Instructions Both CSF and serum samples required, preferably collected at the same time (not more than 72 hours). CSF specimen label must contain the date the sample was collected and the legible name of the person who collected the sample.
Container type CSF tube or sterile collection tube and Gold top
Amount to Collect 1 mL CSF AND 1 mL blood
Sample type CSF AND Serum
Preferred volume 1 mL CSF AND 0.5 mL serum
Min. Volume 0.5 ML CSF AND 0.5 mL serum
UCSF Rejection Criteria Lipemic samples
Processing notes Order IGGI for CSF and IGGIS for serum. Freeze samples at -20oC
Units mg/dL
Normal range
CSF IgG 0.3-4.3 mg/dL
CSF Albumin 5.4-31.8 mg/dL
Serum IgG (> 10 year old) 672-1760 mg/dL
Serum Albumin (> 18 year old) 3600-4800 mg/dL
IgG Index, CSF 0.3-0.6
Turn around times 1-8 days
Additional information Index = (CSF IgG/Albumin)/ (serum IgG/Albumin)

Reference range data applies only to lumbar CSF. Contamination of CSF with blood due to a traumatic LP can significantly elevate the IgG index.

CSF IgG, albumin and index reference ranges from: Tietz Textbook of Clinical Chemistry; 3rd ed., 1999, and Fishman, R.A., Cerebrospinal Fluid in Diseases of the Nervous System; 2nd ed., 1992.

See also Oligoclonal bands.

Immunoelectrophoresis is not offered on CSF.
CPT coding 82784; 82040; 83883; 82784
Last Updated 7/5/2017 5:02:39 PM
Entry Number 560
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