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Lab Manual for Moffitt-Long and Mount Zion

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Islet Cell Antibody

Item Value
Approval req'd? No
Available Stat? No
Test code ICAB
Performed by Quest
Sendout? Yes
Method Immunofluorescence
Container type Red top
Amount to Collect 4 mL blood
Sample type Serum
Preferred volume 2 mL serum
Min. Volume 0.5 mL serum
Processing notes Order Quest #52654P
Normal range Negative
Stability Room temperature two days, refrigerated two weeks, frozen at -20C six months.
Turn around times Test performed Monday-Friday (AM). Turnaround 3-5 days
Reflex? Yes, if positive titer will be performed at an additional charge
Additional information Islet cell antibody titer reported in JDF units (Reference Range: less then 1.25 JDF). End point titers are compared to a single international reference standard and values are reported in JDF (Juvenile Diabetes Foundation) units.

Type 1 diabetes is characterized by lymphocytic cell infiltrate of the pancreatic islets. Measurement of GAD-65, ICA-512, and Insulin Antibody is a highly sensitive means to assess risk and predict onset of Type I diabetes. There is a correlation between the number of positive antibodies and the antibody titers versus the severity of the autoimmune process.
LOINC code 45171-6
Last Updated 10/2/2010 11:52:08 AM
Entry Number 548
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