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Lab Manual for Moffitt-Long and Mount Zion

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Homovanillic Acid, random urine

Item Value
Approval req'd? No
Available Stat? No
Test code HVAR
Test group Homovanillic
Performed by Quest
Sendout? Yes
Method HPLC, ECD
Patient Preparation It is preferable for the patient to be off medications for three days prior to collection. However, common antihypertensives (diuretics, ACE inhibitors, calcium channel blockers, alpha and beta blockers) cause minimal or no interference. Patient should avoid alcohol, coffee, tea, tobacco and strenuous exercise prior to collection.
Container type Urine cup
Amount to Collect See preferred volume
Sample type Random urine
Preferred volume 10 mL urine
Min. Volume 5 mL urine
Processing notes Preferably the sample should be acidified with 6N HCl (or boric acid) to pH < 3. Quest will accept samples from IMMEDIATELY after collection at -20C. Ship frozen. Order Quest Test #84855N.

Samples for Brown & Toland patients MUST be acidified or LabCorp will reject. Order test # 120246
Units mg/g creatinine
Normal range Homovanillic acid in random urine:
Birth-6 months 9.1-36 mg/g creatinine
7-11 months 11.2-33 mg/g creatinine
1-2 years 8.5-38 mg/g creatinine
3-8 years 2.1-23 mg/g creatinine
9-12 years 1.1-12 mg/g creatinine
≥ 18 year olds 1.4-5.3 mg/g creatinine


Creatinine in random urine:
Birth-6 months 0.02-0.32 g/L
7-11 months 0.02-0.36 g/L
1-2 years 0.02-1.28 g/L
3-8 years 0.2-1.49 g/L
9-12 years 0.02-1.83 g/L
≥ 18 year olds 0.27-3.00 g/L
Synonyms HVA
Turn around times Test run four days a week. Reports in two days.
Additional information Homovanillic acid (HVA, 4-hydroxy-3-methoxyphenylacetic acid) has been identified as the principal urinary metabolite of dopa and dopamine. HVA is excreted in free form in relatively large amounts, and is frequently measured to support a diagnosis of neuroblastoma and malignant pheochromocytoma. HVA has been used to monitor chronic lead exposure and response to medication during the treatment of Parkinson's disease.
LOINC code 11146-8
Last Updated 3/24/2013 7:49:36 PM
Entry Number 536

If you have additional questions regarding this test, please call: 415-353-1667

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