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Hantavirus Antibodies (IgG & IgM)

Item Value
Approval req'd? No
Available Stat? No
Test code HANTA
Test group Hantavirus
Performed by Focus via Quest
Sendout? Yes
Method ELISA
Container type Red top (Gold top acceptable)
Amount to Collect 2 mL blood
Sample type Serum
Preferred volume 1 mL serum
Min. Volume 0.25 mL serum
Processing notes Refrigerate sample at 4C. Order Quest #37547X
Units Index
Normal range
≤ 1.10 Antibody not detected
> 1.10 Antibody detected
Synonyms Sin nombre antibodies
Turn around times Set up 6 days a week. Turnaround 2-4 days
Reflex? If Hantavirus IgG is > 1.10 and Hantavirus IgM is >1.10 then Sin Nombre Virus IgG Comfirmation will be performed at an additional charge by the reference lab.
Additional information Two major groups of hantaviruses are recognized based on clinical presentation. The first group includes Sin Nombre Virus (SNV), which causes hantavirus pulmonary syndrome, a severe and sometimes fatal form of acute respiratory distress. A second group of hantaviruses (including Seoul, Hantaan, Dobrava, and Puumala) causes hemorrhagic fever with renal syndrome, a condition not typically seen in the United States.

Sera are initially screened for IgG and IgM antibodies recognizing the nucleocapsid protein common to all hantaviruses. All screen IgM positive samples are then tested for SNV-specific IgM; any screen IgM positive samples that are also screen IgG positive are tested for SNV-specific IgG, as well as SNV-specific IgM. Samples that are screen IgG positive but screen IgM negative are not subjected to SNV-specific IgG testing, since the lack of IgM rules out acute SNV infection. A positive screening result but a negative SNV-specific antibody result may indicate either reactivity to a hantavirus other than SNV or false positive reactivity. A small number of SNV IgM positive (but screen IgG negative) samples represent false positive reactivity associated with acute cytomegalovirus or Epstein Barr virus infection.

These assays were developed and their performance characteristics have been determined by Focus Diagnostics. They have not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. Performance characteristics refer to the analytical performance of the
CPT coding 86790-90 x2
LOINC code 16928-4
Last Updated 10/2/2010 11:52 AM
Entry Number 460
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