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Gliadin Antibodies, Deamidated (IgG and IgA)

Item Value
Approval req'd? No
Available Stat? No
Test code GLIA
Performed by Immunology
In House Availability Friday (day shift)
Method Chemiluminescence
Collection Instructions Avoid hemolysis
Container type Gold top
Amount to Collect 2 mL blood
Sample type Serum
Preferred volume 1 mL serum
Min. Volume 0.5 mL serum
UCSF Rejection Criteria Grossly hemolyzed or icteric samples
Processing notes Freeze serum at -20°C
Units Chemiluminescence units (CU)
Normal range Gliadin antibody (IgG)
Negative < 20.0 CU
Weak Positive 20.0-30.0 CU
Positive > 30.0 CU

Gliadin Antibody (IgA)
Negative < 20.0 CU
Weak Positive 20.0-30.0 CU
Positive > 30.0 CU
Synonyms Celiac disease; gluten sensitive enteropathy; anti deamidated gliadin antibodies
Turn around times 2-8 days
Additional information Anti-gliadin antibodies are associated with Celiac Disease (also called gluten-sensitive enteropathy). IgG and/or IgA antibodies can be found, but generally, IgA antibodies are considered more specific for disease, while IgG antibodies are considered more sensitive. This assay uses the deamidated form of gliadin as a substrate, which is considered to have greater diagnostic accuracy in comparison with traditional assays. Testing for antibodies to TTG (tissue transglutaminase) are usually performed in addition to testing for antibodies to gliadin.

Note: Since IgA deficiency is common in patients with celiac disease, serum IgA levels may be useful in patients with negative results for the IgA anti-gliadin assay.
LOINC code 57776-7
Last Updated 2/20/2015 8:26:32 AM
Entry Number 420
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