UCSF Navigation Bar

UCSF Departments of Pathology & Laboratory Medicine Home Page

Lab Manual for UCSF Clinical Laboratories

Lab Manual for SFGH

Internal Resources

Click here for more information about laboratory operations and procedures

If you have additional questions regarding this test, please call: 415-353-1667

Search Our Test Menu

Gastric Parietal Cell Antibody

Item Value
Approval req'd? No
Available Stat? No
Test code GPCA
Performed by Quest
Sendout? Yes
Method ELISA
Container type Red top
Amount to Collect 2 mL blood
Sample type Serum
Preferred volume 1 mL serum
Min. Volume 0.3 mL serum
Processing notes Freeze sample. Order Quest #15114X
Units Units
Normal range
Negative ≤ 20.0 Units
Equivocal 20.1-24.9 Units
Positive ≥ 25.0 Units
Synonyms anti-parietal cell antibody; parietal cell antibodies
Additional information Pernicious anemia is a chronic disease and is the end stage of type A (autoimmune) chronic atrophic gastritis. The type A chronic atrophic gastritis affects the fundus and body of the stomach, while type B (nonimmune, associated with H. pylori infection) affects the antrum as well as the secretory canaliculi and the tubulovesicles of the gastric parietal cells. This antigen has been identrified as the gastric H+/K+ ATPase (gastric proton pump). GPA bind to both the alpha and beta subunits of the H+/K+ ATPase.

GPA prevalence increases with age and has been reported in 2.5% of a normal population 30-39 years old and in 9.6% of a population in their 8th decade.
LOINC code 56147-2
Last Updated 10/2/2010 11:51:55 AM
Entry Number 415
UCSF home page UCSF home page About UCSF Search UCSF UCSF Medical Center