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Gastric Parietal Cell Antibody

Item Value
Approval req'd? No
Available Stat? No
Test code GPCA
Performed by Quest
Sendout? Yes
Method ELISA
Container type Red top
Amount to Collect 2 mL blood
Sample type Serum
Preferred volume 1 mL serum
Min. Volume 0.3 mL serum
Processing notes Freeze sample. Order Quest #15114X
Units Units
Normal range
Negative ≤ 20.0 Units
Equivocal 20.1-24.9 Units
Positive ≥ 25.0 Units
Synonyms anti-parietal cell antibody; parietal cell antibodies
Additional information Pernicious anemia is a chronic disease and is the end stage of type A (autoimmune) chronic atrophic gastritis. The type A chronic atrophic gastritis affects the fundus and body of the stomach, while type B (nonimmune, associated with H. pylori infection) affects the antrum as well as the secretory canaliculi and the tubulovesicles of the gastric parietal cells. This antigen has been identrified as the gastric H+/K+ ATPase (gastric proton pump). GPA bind to both the alpha and beta subunits of the H+/K+ ATPase.

GPA prevalence increases with age and has been reported in 2.5% of a normal population 30-39 years old and in 9.6% of a population in their 8th decade.
CPT coding 83516-90
LOINC code 56147-2
Last Updated 6/21/2016 08:23:35
Entry Number 415
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