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Gastric Parietal Cell Antibody
|Container type||Red top|
|Amount to Collect||2 mL blood|
|Preferred volume||1 mL serum|
|Min. Volume||0.3 mL serum|
|Processing notes||Freeze sample. Order Quest #15114X|
|Synonyms||anti-parietal cell antibody; parietal cell antibodies|
|Additional information||Pernicious anemia is a chronic disease and is the end stage of type A (autoimmune) chronic atrophic gastritis. The type A chronic atrophic gastritis affects the fundus and body of the stomach, while type B (nonimmune, associated with H. pylori infection) affects the antrum as well as the secretory canaliculi and the tubulovesicles of the gastric parietal cells. This antigen has been identrified as the gastric H+/K+ ATPase (gastric proton pump). GPA bind to both the alpha and beta subunits of the H+/K+ ATPase.
GPA prevalence increases with age and has been reported in 2.5% of a normal population 30-39 years old and in 9.6% of a population in their 8th decade.
|Last Updated||10/2/2010 11:51:55 AM|