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Ganglioside Antibodies

Item Value
Approval req'd? No
Available Stat? No
Test code MOLT (Order in Apex as 'Miscellaneous Outside Lab Test' using the complete test name above)
Performed by Quest
Sendout? Yes
Method EIA
Collection Instructions List the specific antibody(-ies) to be tested for in APeX or on a requisition
Container type Gold top
Amount to Collect 6 mL blood
Sample type Serum
Preferred volume 3 mL serum
Min. Volume 1 mL serum
Processing notes Refrigerate sample
Normal range
Synonyms GM-1 antibodies; Asialo-GM1 antibodies; GQ1B; Anti-GM1 antibodies;
Additional information Restricted to Neurology Service.

High titers are seen in > 90% of patients with multifocal motor neuropathy, and very high titers are particularly suggestive of a motor neuropathy. However, they may also be seen in amyotrophic lateral sclerosis, other lower motor neuron syndromes, and autoimmune disorders, and titers by themselves do not indicate the presence of a treatable motor neuron syndrome.

For specimens showing elevated IgM anti-GM1 antibodies, the antibody titers to a 17,000 MW neural protein (the Cy protein) and to the neural protein NP9 are also determined. High antibody titers to GM1 and to NP9 combined with low titers to Cy (Cy Ratio < 0.79) are 80- 90% specific for multifocal motor neuropathy or a lower motor syndrome; 90% of patients with high anti-GM1 levels and a Cy Ratio > 0.79 have Amyotrophic Lateral Sclerosis, peripheral neuropathy or other immune disorders.
Last Updated 2/20/2014 3:06:36 PM
Entry Number 413
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