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Ferritin

Item Value
Clinical Questions Does my patient have hemophagocytic lymphohistiocytosis?
Does my patient have thalassemia?
Does my patient have anemia due to a nutritional deficiency?
Does my patient have hemochromatosis?
Approval req'd? For testing outside of normal test availability (e.g. weekend testing) contact Laboratory resident on-call at x3-1667
Available Stat? No
Test code FERR
Performed by China Basin Chemistry
In House Availability Test available on day shift, 7 days per week.
Method Chemiluminescent Microparticle Immunoassay (Abbott Architect i1000)
Container type Gold top (preferred). Red or Lt. Green top acceptable
Amount to Collect 1 mL blood
Sample type Serum (preferred) or Heparinized plasma
Preferred volume 0.5 mL serum or plasma
Min. Volume 0.25 mL serum or plasma
Processing notes Refrigerate
Units µg/L
Normal range PEDIATRIC REFERENCE RANGE

AGE MALE (ng/mL) FEMALE (ng/mL)
4 – 14 days 100 – 717 100 – 717
15 days - < 6 months 14 – 647 14 – 647
6 months - < 1 year 8 – 182 8 – 182
1 – 5 years 5 – 100 5 – 100
5 - < 14 years 14 – 79 14 – 79
14 – < 16 years 13 – 83 5 – 67
16 - < 19 years 11 – 172 5 – 67


Pediatric reference ranges adopted from CALIPER Pediatric Reference Interval study performed on random samples using the Abbott Architect i2000 assay.

ADULT REFERENCE RANGE

AGE MALE (ng/mL) FEMALE (ng/mL)
19 – 29 years 38 – 270 12 – 114
30 – 39 years 48 – 420 12 – 160
40 – 49 years 30 – 490 12 – 240
50 years and older 30 – 530 18 – 340


Adult reference ranges adopted from ARUP Laboratories based on correlation studies using patient samples.

Stability Refrigerated (2-8°C): 7 days
Freezer (-10°C or colder): 12 months
Turn around times 1 day
Additional information Ferritin is a more sensitive test of iron stores than serum iron, transferrin saturation (saturation of iron-binding capacity) or RBC indices. Iron-deficient erythropoiesis begins at ferritin levels of 25-40 µg/L, within the reference range; a cutoff level of 16 yields a sensitivity of 75% and a specificity of 98% (Hallberg L et al. Br J Haematol 1993;85:787).

Markedly elevated levels may be seen in some infections, in hemochromatosis, in patients with repeated red cell transfusions (e.g. thalassemia) and in Hemophagocytic Lymphohistiocytosis (HLH)

Grossly hemolysed samples may give falsely elevated results by as much as 60% due to the release of intracellular ferritin.

If a sample is found to be grossly hemolyzed (>200 mg/dL hemogloin, (hemolytic index >5)), add an ETC comment "HEMIN" (hemolysis present, may tend to increase result)."
CPT coding 82728
LOINC code 2276-4
Last Updated 11/30/2016 5:24:52 PM
Entry Number 377
Lab Procedure Link Click here for Procedure
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