Click here for more information about laboratory operations and procedures
If you have additional questions regarding this test, please call: 415-353-1667
|Test Update Information||Method changed from Siemens Centaur XP platform to Abbott Architect i1000 platform on December 1, 2016. Please note that the reference ranges have changed.|
|Clinical Questions||Does my patient have hemophagocytic lymphohistiocytosis?
Does my patient have thalassemia?
Does my patient have anemia due to a nutritional deficiency?
Does my patient have hemochromatosis?
|Approval req'd?||For testing outside of normal test availability (e.g. weekend testing) contact Laboratory resident on-call at x3-1667|
|Performed by||China Basin Chemistry|
|In House Availability||Test available on day shift, 7 days per week.|
|Method||Chemiluminescent Microparticle Immunoassay (Abbott Architect i1000)|
|Container type||Gold top (preferred). Red or Lt. Green top acceptable|
|Amount to Collect||1 mL blood|
|Sample type||Serum (preferred) or Heparinized plasma|
|Preferred volume||0.5 mL serum or plasma|
|Min. Volume||0.25 mL serum or plasma|
|Normal range|| PEDIATRIC REFERENCE RANGE
Pediatric reference ranges adopted from CALIPER Pediatric Reference Interval study performed on random samples using the Abbott Architect i2000 assay.
ADULT REFERENCE RANGE
Adult reference ranges adopted from ARUP Laboratories based on correlation studies using patient samples.
|Stability||Refrigerated (2-8°C): 7 days
Freezer (-10°C or colder): 12 months
|Turn around times||1 day|
|Additional information||Ferritin is a more sensitive test of iron stores than serum iron, transferrin saturation (saturation of iron-binding capacity) or RBC indices. Iron-deficient erythropoiesis begins at ferritin levels of 25-40 µg/L, within the reference range; a cutoff level of 16 yields a sensitivity of 75% and a specificity of 98% (Hallberg L et al. Br J Haematol 1993;85:787).
Markedly elevated levels may be seen in some infections, in hemochromatosis, in patients with repeated red cell transfusions (e.g. thalassemia) and in Hemophagocytic Lymphohistiocytosis (HLH)
Grossly hemolysed samples may give falsely elevated results by as much as 60% due to the release of intracellular ferritin.
If a sample is found to be grossly hemolyzed (>200 mg/dL hemogloin, (hemolytic index >5)), add an ETC comment "HEMIN" (hemolysis present, may tend to increase result)."
|Last Updated||2/3/2017 4:25:24 PM|
|Lab Procedure Link||Click here for Procedure|