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Ferritin

Item Value
Clinical Questions Does my patient have hemophagocytic lymphohistiocytosis?
Does my patient have thalassemia?
Does my patient have anemia due to a nutritional deficiency?
Does my patient have hemochromatosis?
Approval req'd? For testing outside of normal test availability (e.g. weekend testing) contact Laboratory resident on-call at x3-1667
Available Stat? No
Test code FERR
Performed by China Basin Chemistry
In House Availability Monday-Friday (day shift)
Method Chemiluminescent immunoassay (Siemens Centaur)
Container type Gold top (preferred). Red or Lt. Green top acceptable
Amount to Collect 1 mL blood
Sample type Serum (preferred) or Heparinized plasma
Preferred volume 0.5 mL serum or plasma
Min. Volume 0.25 mL serum or plasma
Processing notes Refrigerate
Units µg/L
Normal range
Males 22-322 µg/L
Females 10-291 µg/L


Reference ranges adopted from Quest Diagnostics based on split Pt. comparison testing using the same instrument/methodology (Siemens Centaur)
Turn around times 1-3 days
Additional information Hemolyzed specimens may give false elevations. Our reference range does not differentiate menstruating and non-menstruating females, but levels are known to approach those in males following menopause.

Ferritin is a more sensitive test of iron stores than serum iron, transferrin saturation (saturation of iron-binding capacity) or RBC indices. Iron-deficient erythropoiesis begins at ferritin levels of 25-40 µg/L, within the reference range; a cutoff level of 16 yields a sensitivity of 75% and a specificity of 98% (Hallberg L et al. Br J Haematol 1993;85:787).

Markedly elevated levels may be seen in some infections, in hemochromatosis, in patients with repeated red cell transfusions (e.g. thalassemia) and in Hemophagocytic Lymphohistiocytosis (HLH)
Medical Necessity? Yes. Click here for more information
LOINC code 2276-4
Last Updated 5/1/2011 5:54:49 PM
Entry Number 377
Lab Procedure Link Click here for Procedure
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