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Antibodies to Extractable Nuclear Antigens
| Item | Value | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Approval req'd? | No | ||||||||
| Available Stat? | No | ||||||||
| Test code | AENA | ||||||||
| Performed by | Immunology | ||||||||
| In House Availability | Wednesday (day shift) | ||||||||
| Method | EIA | ||||||||
| Container type | Gold top | ||||||||
| Amount to Collect | 1 mL blood | ||||||||
| Sample type | Serum | ||||||||
| Preferred volume | 0.5 mL serum | ||||||||
| Processing notes | Freeze serum at -20C | ||||||||
| Units | Units | ||||||||
| Normal range | For both anti-SM and anti-SM/RNP:
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| Synonyms | ENA; anti-SM; anti-RNP; anti-ENA; anti-smith; RNP antibody; Sm antibody; Smith antibody; Sm/RNP | ||||||||
| Turn around times | 2-9 days | ||||||||
| Additional information | Systemic lupus erythematosus (SLE) is characterized by the presence of autoantibodies. One class of autoantibodies is directed against extractable nuclear antigens, often producing a speckled pattern on ANA screening. Antibodies to Sm are present in approximately 40% of patients with SLE and are considered to be highly specific markers for this disease. The RNP antigen is closely associated with the Sm antigen and is designated the Sm/RNP complex. Anti-RNP antibodies are found in a variety of rheumatic diseases including scleroderma, rheumatoid arthritis, discoid lupus, polymyositis, and Sjogren's syndrome. Testing is performed against the Sm antigen alone and against the Sm/RNP complex (testing for RNP alone is not available) Weak positive results may not have clinical significance. Clinical correlation is advised. Repeat testing may be considered, if clinical indicated |
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| LOINC code | 43182-5 | ||||||||
| Last Updated | 5/1/2011 4:34:34 PM | ||||||||
| Entry Number | 338 |
If you have additional questions regarding this test, please call: 415-353-1667