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Antibodies to Extractable Nuclear Antigens
|In House Availability||Wednesday (day shift)|
|Container type||Gold top|
|Amount to Collect||1 mL blood|
|Preferred volume||0.5 mL serum|
|Processing notes||Freeze serum at -20C|
|Normal range|| For both anti-SM and anti-SM/RNP:
|Synonyms||ENA; anti-SM; anti-RNP; anti-ENA; anti-smith; RNP antibody; Sm antibody; Smith antibody; Sm/RNP|
|Turn around times||2-9 days|
|Additional information||Systemic lupus erythematosus (SLE) is characterized by the presence of autoantibodies. One class of autoantibodies is directed against extractable nuclear antigens, often producing a speckled pattern on ANA screening.
Antibodies to Sm are present in approximately 40% of patients with SLE and are considered to be highly specific markers for this disease.
The RNP antigen is closely associated with the Sm antigen and is designated the Sm/RNP complex. Anti-RNP antibodies are found in a variety of rheumatic diseases including scleroderma, rheumatoid arthritis, discoid lupus, polymyositis, and Sjogren's syndrome.
Testing is performed against the Sm antigen alone and against the Sm/RNP complex (testing for RNP alone is not available)
Weak positive results may not have clinical significance. Clinical correlation is advised. Repeat testing may be considered, if clinical indicated
|Last Updated||4/21/2014 9:18:49 AM|