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Epstein-Barr virus Antibodies

Item Value
Approval req'd? No
Available Stat? No
Test code EBV
Test group EBV
Performed by Immunology
In House Availability Monday and Friday (day shift)
Method Chemiluminescent Immunoassay
Container type Gold top
Amount to Collect 2 mL blood
Sample type Serum
Preferred volume 1 mL serum
Min. Volume 0.5 mL serum
Processing notes Freeze serum at -20C.
Normal range
IgM anti-VCA Neg
Anti-EBNA Neg
Synonyms EBV; anti-EA; anti-EA/D; Anti-EA/R; Anti-early antigen; anti-ebna; anti-vca; ea antibody; ea/d antibody; ea/r antibody; early antigen; ebna antibody; IgM anti-VCA; VCA antibody
Turn around times 1-4 days
Additional information The components of this test are IgM anti-VCA (Viral Capsid Antigen) and IgG anti-EBNA-1 (Epstein-Barr Nuclear Antigen-1).

The presence of IgM anti-VCA antibodies is indicative of acute infection.

The presence of IgG anti-EBNA antibodies is indicative of prior exposure or infection with EBV.

The heterophile agglutination test is recommended for routine screening for acute infectious mononucleosis rather than this test.

Results are reported as 'Positive', 'Negative', or Equivocal'. Equivocal results may represent low-titer antibody in early infection; testing may be repeated, if clinically indicated.

The so-called 'early' antibodies to EA/D and EA/R may or may not be present in acute or prior infection, while the titer of IgG anti-VCA is elevated in both acute and prior infection. Since these antibodies offer no additional information, testing for these antibodies is not offered.

EBV antibodies CANNOT be used to diagnose "chronic" or recurrent mononucleosis.

If initial tests are negative in acute illness, do not repeat for at least 3-4 weeks.
CPT coding 86665; 86664
LOINC code 5156-5; 24115-8
Last Updated 11/12/2017 11:12:28 PM
Entry Number 331
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