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Drugs of Abuse Screening Panel (In-house; Not for drug monitoring)

Item Value
Test Update Information Effective 01/14/2013, the platform used for the immunoassays used in this drugs of abuse screen has changed from the Abbott Axsym to the Beckman UniCel DxC 800
Approval req'd? No
Available Stat? Yes
Utilization Guidelines The primary use of this immunoassay is to screen for illicit use of commonly abused drugs when there is a suspicion that drug use may be contributing to the clinical picture (e.g. altered mental status, coma).

Due to extensive cross reactivity and the inability of this assay to detect commonly prescribed medications (e.g. methadone) it is not useful for determine patient adherence to therapeutic regimens or potential drug diversion. For this purpose order specific drug tests (e.g. Opiate confirmation, urine).
Test code DAU
Test group Drug screening
Performed by Parnassus & Mission Bay Chemistry
In House Availability Test available 24 hours per day 7 days per week
Method Enzyme immunoassay method (Beckman UniCel DxC 800 analyzer)
Container type Urine cup
Amount to Collect See preferred volume
Sample type Random urine
Preferred volume 5 mL urine
Min. Volume 1.5 mL urine (insufficient for confirmation)
Processing notes Refrigerate. If requested freeze excess sample not used for this test for possible confirmatory testing at -20C

Confirmatory testing can be ordered for the specific class of agent found using the following test order codes:

Amphetamines AMPC Quest # 214Z
Barbiturates BARC Quest # 8416Z
Benzodiazepines BENC Quest # 14967X
Cocaine metabolite COCAC Quest # 37201X
Opiates OPIAC Quest # 6232Z
THC (Cannabinoids) THCC Quest # 4846Z
Units µg/L
Normal range Negative

(Note: a negative result indicates that the specific class of drugs is not present, or is present at a concentration below that of the cut off concentration. See each drug class for specific concentration cut-offs).
Synonyms amphetamines; barbiturates; cocaine; opiates; benzodiazepines; THC; cannabinoids; cannibis; cocaine metabolites; benzoylecgonine
Stability Refrigerated 1 week, frozen 2 weeks
Turn around times Stat 2 hours, Routine 4 hours
Additional information This test is NOT useful for the detection or monitoring of prescribed opiates such as methadone, oxycodone, codeine or therapeutic level of hydromorphone, or hydrocodone. (See cross reactivity information below

This test is not recommended for neonates where there is a question of maternal drug abuse as it is not as sensitive as the Quest drug screen panel in meconium (Quest #453X: Drug Screen Panel 4, Meconium; required specimen: 5g of meconium).

This test panel screens for the presence of: Amphetamines, Barbiturates, Benzodiazepine, Cocaine (as benzoylecgonine), Cannabinoids and Opiates.

Each of the above panel components can be ordered separately.

This testing is performed using immunologic methods therefore these assays may cross-react with similar compounds. A listing of the cross-reactivities is available:




Cocaine metabolite


THC (Cannabinoids)

Detection Cutoff Limits:

Drug/metabolite Cutoff Reported as
Amphetamines <1000 µg/L NEG
Barbiturates <200 µg/L NEG
Benzodiazepines <200 µg/L NEG
Cocaine metabolite <300 µg/L NEG
Opiates <300 µg/L NEG
Cannabinoids <50 µg/L NEG

CAUTION!: Presumptive screening test only. Cross reactions and false-positive results may occur within each drug class. However, positive results are NOT routinely confirmed by a second method. If confirmation of the test result is required, it is the responsibility of the physician to separately order a specific confirmatory test for the drug(s) identified. False negative results can also occur in presence of low drug concentrations or drugs/metabolites that do not react in the assay [Click on the name of the drug(s) of interest from the list above for more information].

This test is NOT useful for the detection or monitoring of prescribed opiates such as methadone or fentanyl, or for therapeutic concentrations of hydromorphone, oxycodone or hydrocodone. (See cross reactivity information above). If use of opiates not detected by this screen is suspected, immunoassay screens can be ordered from Quest [e.g. methadone (Quest# 7176Z) and fentanyl (Quest#4175U)]. Additionally, an opiate confirmation can be ordered from Quest (OPIAC) that will determine the presence of codeine, morphine, hydrocodone and hydromorphone.

Typical Urine Detection Window after use:

Drug Detection Time (hrs) Max. Detection Time (days)
Amphetamine 24 9
Methamphetamine 87+/-51 6
Cannabis 34 95
Cocaine 48-72 22
Morphine 11-54 11
Barbiturates 24 1-4 (Phenobarbital)
Benzodiazepines 6 14 or longer in chronic users

From: Verstraete AG. Detection Times of Drugs of Abuse in Blood, Urine and Oral Fluid. Ther Drug Monit, 26(2) April 2004, 200-205

Results cannot be used for Medico-legal purposes.

Confirmatory testing can be ordered for the specific class of agent found using the following test order codes:

Amphetamines AMPC Quest# 214Z
Barbiturates BARC Quest# 8416Z
Benzodiazepines BENC Quest# 14967X
Cocaine metabolite COCAC Quest# 37201X
Opiates OPIAC Quest# 6232Z
THC (Cannabinoids) THCC Quest# 4846Z

Confirmatory testing performed Monday-Friday with a 3-6 day turn around time after receipt by reference laboratory.

See also Drug Screening and individual drug entries.
CPT coding 80301 x6
Last Updated 6/27/2016 15:34:35
Entry Number 327
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