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Drugs of Abuse Screen (In-house; Not for drug monitoring)
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| Test Update Information | Effective 01/14/2013, the platform used for the immunoassays used in this drugs of abuse screen has changed from the Abbott Axsym to the Beckman UniCel DxC 800 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Approval req'd? | No | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Available Stat? | Yes | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Utilization Guidelines | The primary use of this immunoassay is to screen for illicit use of commonly abused drugs when there is a suspicion that drug use may be contributing to the clinical picture (e.g. altered mental status, coma). Due to extensive cross reactivity and the inability of this assay to detect commonly prescribed medications (e.g. methadone) it is not useful for determine patient adherence to therapeutic regimens or potential drug diversion. For this purpose order specific drug tests (e.g. Opiate confirmation, urine). |
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| Test code | DAU | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Test group | Drug screening | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Performed by | Parnassus Chemistry | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| In House Availability | Test available 24 hours per day 7 days per week | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Method | Enzyme immunoassay method (Beckman UniCel DxC 800 analyzer) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Container type | Urine cup | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Amount to Collect | See preferred volume | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Sample type | Random urine | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Preferred volume | 5 mL urine | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Min. Volume | 1.5 mL urine (insufficient for confirmation) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Processing notes | Refrigerate. If requested freeze excess sample not used for this test for possible confirmatory testing at -20C Confirmatory testing can be ordered for the specific class of agent found using the following test order codes:
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| Units | µg/L | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Normal range | Negative (Note: a negative result indicates that the specific class of drugs is not present, or is present at a concentration below that of the cut off concentration. See each drug class for specific concentration cut-offs). |
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| Synonyms | amphetamines; barbiturates; cocaine; opiates; benzodiazepines; THC; cannabinoids; cannibis; cocaine metabolites; benzoylecgonine | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Stability | Refrigerated 1 week, frozen 2 weeks | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Turn around times | Stat 2 hours, Routine 4 hours | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Additional information | This test is NOT useful for the detection or monitoring of prescribed opiates such as methadone, oxycodone, codeine or therapeutic level of hydromorphone, or hydrocodone. (See cross reactivity information below This test is not recommended for neonates where there is a question of maternal drug abuse as it is not as sensitive as the Quest drug screen panel in meconium (Quest #453X: Drug Screen Panel 4, Meconium; required specimen: 5g of meconium). This test panel screens for the presence of: Amphetamines, Barbiturates, Benzodiazepine, Cocaine (as benzoylecgonine), Cannabinoids and Opiates. Each of the above panel components can be ordered separately. This testing is performed using immunologic methods therefore these assays may cross-react with similar compounds. A listing of the cross-reactivities is available: Amphetamines Barbiturates Benzodiazepines Cocaine metabolite Opiates THC (Cannabinoids) Detection Cutoff Limits:
CAUTION!: Presumptive screening test only. Cross reactions and false-positive results may occur within each drug class. However, positive results are NOT routinely confirmed by a second method. If confirmation of the test result is required, it is the responsibility of the physician to separately order a specific confirmatory test for the drug(s) identified. False negative results can also occur in presence of low drug concentrations or drugs/metabolites that do not react in the assay [Click on the name of the drug(s) of interest from the list above for more information]. This test is NOT useful for the detection or monitoring of prescribed opiates such as methadone or fentanyl, or for therapeutic concentrations of hydromorphone, oxycodone or hydrocodone. (See cross reactivity information above). If use of opiates not detected by this screen is suspected, immunoassay screens can be ordered from Quest [e.g. methadone (Quest# 7176Z) and fentanyl (Quest#4175U)]. Additionally, an opiate confirmation can be ordered from Quest (OPIAC) that will determine the presence of codeine, morphine, hydrocodone and hydromorphone. Typical Urine Detection Window after use:
From: Verstraete AG. Detection Times of Drugs of Abuse in Blood, Urine and Oral Fluid. Ther Drug Monit, 26(2) April 2004, 200-205 Results cannot be used for Medico-legal purposes. Confirmatory testing can be ordered for the specific class of agent found using the following test order codes:
Confirmatory testing performed Monday-Friday with a 3-6 day turn around time after receipt by reference laboratory. See also Drug Screening and individual drug entries. |
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| Last Updated | 3/24/2013 7:40:27 PM | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Entry Number | 327 |
If you have additional questions regarding this test, please call: 415-353-1667