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|Test Update Information||On 09/07/2010, the calibrators for the digoxin assay were modified to be traceable to mass spectrometry standardization. The change in assay calibration caused an increase in digoxin results between 0.1 - 0.4 micrograms/L|
|Performed by||Parnassus Chemistry|
|In House Availability||Test available 24 hours per day 7 days per week|
|Method||Turbidimetric Inhibition immunoassay|
|Collection Instructions||Time to steady state: 3-5 days
Collect samples 30 minutes before next dose or at least 6-8 hours post dose.
|Container type||Gold top or Light Green top|
|Amount to Collect||1 mL blood|
|Sample type||Serum or plasma|
|Preferred volume||0.5 mL serum or plasma|
|Min. Volume||0.3 mL serum or plasma|
|Processing notes||Refrigerate serum.|
|Normal range||Therapeutic: 0.5-2.0 µg/L|
|Critical value||> 2.0 ug/L|
|Turn around times||STAT 1 hour, Routine 4 hours|
|Additional information||Non-specific immunologic CROSS-REACTIVITY can occur in patients with renal failure, pregnant women and neonates.
Note: In patients receiving Digibind therapy for treatment of digoxin overdose, the measured levels of digoxin are unreliable and may accurately reflect neither the total level of digoxin (bound and free) nor the level of free digoxin.
Although offered Stat, therapeutic decisions are typically not altered by stat results except in cases of accidental massive overdose when Digibind therapy is contemplated. Due to the long T1/2 for Digoxin it is generally acceptable to merely hold the next dose and obtain a routine Digoxin level.
Click here for A guide on Drug Level Monitoring
|Medical Necessity?||Yes. Click here for more information|
|Last Updated||1/30/2013 1:49:28 PM|
|Lab Procedure Link||Click here for Procedure|