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Lab Manual for Moffitt-Long and Mount Zion

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Digoxin

Item Value
Test Update Information On 09/07/2010, the calibrators for the digoxin assay were modified to be traceable to mass spectrometry standardization. The change in assay calibration caused an increase in digoxin results between 0.1 - 0.4 micrograms/L
Approval req'd? No
Available Stat? Yes
Test code DIG
Performed by Parnassus Chemistry
In House Availability Test available 24 hours per day 7 days per week
Method Turbidimetric Inhibition immunoassay
Collection Instructions Time to steady state: 3-5 days

Collect samples 30 minutes before next dose or at least 6-8 hours post dose.
Container type Gold top or Light Green top
Amount to Collect 1 mL blood
Sample type Serum or plasma
Preferred volume 0.5 mL serum or plasma
Min. Volume 0.3 mL serum or plasma
Processing notes Refrigerate serum.
Units µg/L
Normal range Therapeutic: 0.5-2.0 µg/L
Critical value > 2.0 ug/L
Synonyms Lanoxin
Turn around times STAT 1 hour, Routine 4 hours
Additional information Non-specific immunologic CROSS-REACTIVITY can occur in patients with renal failure, pregnant women and neonates.

Note: In patients receiving Digibind therapy for treatment of digoxin overdose, the measured levels of digoxin are unreliable and may accurately reflect neither the total level of digoxin (bound and free) nor the level of free digoxin.

Although offered Stat, therapeutic decisions are typically not altered by stat results except in cases of accidental massive overdose when Digibind therapy is contemplated. Due to the long T1/2 for Digoxin it is generally acceptable to merely hold the next dose and obtain a routine Digoxin level.

Click here for A guide on Drug Level Monitoring
Medical Necessity? Yes. Click here for more information
LOINC code 10535-3
Last Updated 1/30/2013 1:49:28 PM
Entry Number 307
Lab Procedure Link Click here for Procedure
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