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Cyclosporine A

Item Value
Approval req'd? No
Available Stat? No
Test code CYCL
Performed by China Basin Chemistry
In House Availability Daily (day shift)
Method Abbott Architect Chemiluminescent Immunoassay
Collection Instructions Time to steady state: 2-5 days

Draw trough samples only (24 hours post dose or just prior to next dose) or normal ranges will not apply.

This very non-polar compound adheres tenaciously to plastic; samples should not be drawn from any line through which the drug has been infused but only from a peripheral site.

NOTE: To avoid testing delays and the possibility of QNS samples, blood for Cyclosporin should be collected as a separate sample. The sample should not be shared for any other test(s).
Container type Lavender top
Amount to Collect 2 mL blood

NOTE: This should be submitted as a unique, separate sample for testing.
Sample type EDTA whole blood
Preferred volume 2 mL blood

NOTE: This should be submitted as a unique, separate sample for testing.
Min. Volume 0.3 mL blood

NOTE: This should be submitted as a unique, separate sample for testing and this minimum volume does not allow for repeat testing if needed.
Processing notes Do not centrifuge
Units µg/L
Normal range
Therapeutic trough 50-500 µg/L
Synonyms Neoral; cyclosporin; CSA; Gengraf; Sandimmune
Turn around times Specimens received in the laboratory by 1200 (Monday.-Friday) and by 1000 (weekends and holidays) will have results available by 1600 the same day.
Additional information Generally recommended therapeutic trough levels vary between 50 to 500. However, there is no universally accepted therapeutic level and the desired concentrations may vary with the indications, e.g., higher for liver than for renal transplantation, higher early in the post-transplant period, higher in threatened or subacute rejection. In a patient who is doing well following liver transplantation a level of 250-300 might be sought for the first 3-4 months , 150-250 for 4 months - 12 months , and lowered to 100-150 after one year, whereas post-renal transplant a well-compensated patient might be kept at 150-300 for 6 months , then reduced to 50-150. The level usually desirable for any given patient may also be adjusted because of intercurrent illness. The current therapeutic range was established in consultation with UCSF transplant physicians and clinical pharmacists.

The Abbott Architect immunoassay for cyclosporine is reported by the manufacturer to show little or no cross reactivity with the major cyclosporine metabolites (see Lab Procedure Link). Results with this immunoassay run approximately 30% higher than results with the previous HPLC assay mainly due to assay calibration differences.

Click here for: A Guide on Drug Level Monitoring
LOINC code 3520-4
Last Updated 11/16/2014 7:06:33 PM
Entry Number 285
Lab Procedure Link Click here for Procedure
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