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Lab Manual for Moffitt-Long and Mount Zion

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Anti-Cyclic Citrullinated Peptide Antibody (IgG)

Item Value
Approval req'd? No
Available Stat? No
Test code CYCP
Performed by Immunology
In House Availability Wednesday (day shift)
Method EIA
Container type Gold top or Red top
Amount to Collect 1 mL blood
Sample type Serum
Preferred volume 0.5 mL serum
Min. Volume 0.3 mL serum
Processing notes Freeze serum at -20C
Units Units
Normal range
Negative < 20 Units
Weak Positive 20.0-39.9 Units
Moderate Positive 40.0-59.9 Units
Strong Positive > 59.9 Units
Synonyms CCP; anti-CCP
Turn around times 2-9 days
Additional information The main clinically useful biologic markers in diagnosis of patients with rheumatoid arthritis (RA) are rheumatoid factor and antibodies to citrullinated peptides. These antibodies may also be useful for prediction of functional and radiographic outcomes. Anti-perinuclear antibodies (also called anti-keratin antibodies) often found in patients with RA recognize an epitope that contains the deimidated form of arginine called citrulline.

This test uses a third generation cyclic citrullinated peptide (CCP) antigen for detection of these antibodies. Presence of these antibodies is thought to be very specific for RA but not as sensitive as rheumatoid factor. Recent studies suggest that use of RF and CCP antibodies together may provide better sensitivity for diagnosis of RA than either alone. Note that at the present time, CCP antibodies are not considered part of the diagnostic criteria for RA. Test results that fall in the weak positive range may be repeated, if clinically indicated for diagnostic purposes, or may reflect treatment of a patient with an existing clinical diagnosis.
LOINC code 33935-8
Last Updated 5/9/2011 11:46:50 AM
Entry Number 283

If you have additional questions regarding this test, please call: 415-353-1667

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