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|In House Availability||Tuesday, Friday (day shift)|
|Collection Instructions||Immediately transport to laboratory in hand, maintain sample at 37C|
|Container type||Gold top|
|Amount to Collect||4 mL blood|
|Preferred volume||2 mL serum|
|UCSF Rejection Criteria||Room temperature or colder sample received.|
|Processing notes||Warm specimen for 1 hour at 37C in heating block; centrifuge immediately thereafter, and aliquot into conical centrifuge tube.|
|Normal range||< 0.12 g/L|
|Turn around times||3-5 days|
|Additional information||If immunofixation (IFE) for a cryoglobulin is requested, a quantitative cryoglobulin is run first to determine whether the quantity of cryoprecipitate is sufficient for IFE analysis. Samples are held for a minimum of 72 hours after receipt before the analysis for cryoglobulin is performed. Cryoglobulinemias are generally classified as:
Type I: Monoclonal antibodies, associated most often with myeloma or lymphoproliferative disorders, and highly correlated with the development of renal disease.
Type II: Most commonly found, these are mixtures of mono- and polyclonal antibodies, and are associated with the various connective tissue diseases and, especially, chronic infection with Hepatitis C, which should be sought in any case of cryoglobulinemia. The cryoglobulin often recognizes portions of the HCV protein envelope and the cryoprecipitates are rich in virus.
Type III: Polyclonal antibodies, associated mainly with lupus erythematosus.
Refs: Brouet J-C et al. Amer J Med 1974; 57:775. Winfield JB. Hum Pathol 1983;14:350.
Johnson RJ et al. N Engl J Med 1993;328:465.
Note: This test was developed and its performance characteristics determined by the Clinical Laboratories at the Medical Center at UC San Francisco. It has not been cleared or approved by the U.S. Food and Drug Administration.
|LDT or Mod FDA?||Yes|
|Last Updated||11/27/2012 5:20:19 PM|
If you have additional questions regarding this test, please call: 415-353-1667