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Lab Manual for Moffitt-Long and Mount Zion

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Creatinine Clearance

Item Value
Approval req'd? Yes, if testing is requested between midnight and 8:00 AM.
Available Stat? No
Test code CRCL
Performed by Parnassus Chemistry
In House Availability Test available 7 days per week from 8:00 AM to midnight only.
Method Spectrophotometric, kinetic (alkaline picrate,Jaffe) assay on Beckman DXC 600/800 analyzers. Calibration traceable to isotope dilution mass spec (IDMS) standardization

Click here for more information on Parnassus assay
Collection Instructions Submit serum (Gold top) drawn within 24 hours of urine collection-preferably within the interval of collection.

Give the weight in kg and height in cm of the patient if a corrected clearance is needed.

Refrigerate the collection container during the collection period.
Container type 24 hour urine collection container AND Gold top

Click here for Urine Preservative Requirements
Amount to Collect Entire 24 hour urine output and
2 mL blood (Gold top)
Sample type 24 hour urine collection or timed urine AND serum
Preferred volume
Urine Complete collection
Serum 1 mL serum
Min. Volume
Urine Complete collection
Serum 0.2 mL serum
UCSF Rejection Criteria Container not refrigerated during collection
Units mL/min/1.73 m2
Normal range
Age Male and Female
0-7 days 17-60 mL/min/1.73 m2
8-30 days 26-68 mL/min/1.73 m2
1-2 months 30-86 mL/min/1.73 m2
3-5 months 39-114 mL/min/1.73 m2
6-11 months 49-157 mL/min/1.73 m2
12-23 months 62-191 mL/min/1.73 m2
2-12 years 89-165 mL/min/1.73 m2


Age Male Female
13-29 years 88-146 mL/min/1.73 m2 81-134 mL/min/1.73 m2
30-39 years 82-140 mL/min/1.73 m2 75-128 mL/min/1.73 m2
40-49 years 75-133 mL/min/1.73 m2 69-122 mL/min/1.73 m2
50-59 years 68-126 mL/min/1.73 m2 64-116 mL/min/1.73 m2
60-69 years 61-120 mL/min/1.73 m2 58-110 mL/min/1.73 m2
≥70 years 55-113 mL/min/1.73 m2 52-105 mL/min/1.73 m2


Pediatric reference ranges from Holliday, Malcolm A; Barratt, T. Martin and Vernier, Robert L. Pediatric Nephrology, 2nd edition Williams & Wilkins and Edelmann, Chester M. Jr. Pediatric Kidney Disease vol 1, Little Brown & Company, Boston MA. Adult reference ranges from Tietz Textbook of Clinical Chemistry 2nd edition,W.B. Saunders Company
Stability Refrigerated 2 days
Turn around times 4 hours
Additional information Note: Clearances are often inaccurate because of incomplete urine collection. A 4- or 6-hour collection is likely to be more complete than the classic 24 hour test, but extrapolation of results from shortened collections may not be accurate.

GFR can also be estimated from serum creatinine measurements without the need for urine creatinine measurements. See the laboratory manual entry on serum creatinine for details on estimating GFR from serum creatinine results.
LOINC code 2164-2
Last Updated 4/13/2012 2:21:50 PM
Entry Number 267
Lab Procedure Link Click here for Procedure

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