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Creatinine, Plasma / Serum

Item Value
Test Update Information Effective November 16, 2016, the UCSF Clinical Labs switched to an enzymatic creatinine assay. Please note updated reference ranges.

Since December 1, 2014, the eGFR has been calculated using the CKD-EPI (2009) equation
Approval req'd? No
Available Stat? Yes
Test code CRG
Test group Creatinine
Performed by Parnassus, Mission Bay & Mt. Zion Chemistry
In House Availability Test available 24 hours per day 7 days per week
Method Enzymatic assay on Beckman DXC 600/800 analyzers. Calibration traceable to isotope dilution mass spec (IDMS) standardization.


Click here for more information about the assay
Container type Light green top preferred, Gold top acceptable
Amount to Collect 1 mL blood Click here for Microdetermination info
Sample type Plasma or serum
Preferred volume 0.5 mL plasma or serum
Min. Volume 0.2 mL plasma or serum
Click here for Microdetermination info
Units Creatinine: mg/dL, eGFR in mL/min/1.73 m2
Normal range Creatinine:
Age Male Female
0 to 14 days 0.30-0.90 mg/dL 0.30-0.90 mg/dL
15 days to < 2 years 0.10-0.30 mg/dL 0.10-0.30 mg/dL
2 to < 5 years 0.20-0.40 mg/dL 0.20-0.40 mg/dL
5 to < 12 years 0.30-0.60 mg/dL 0.30-0.60 mg/dL
12 to < 15 years 0.40-0.80 mg/dL 0.40-0.80 mg/dL
15 to < 19 years 0.60-1.00 mg/dL 0.50-0.80 mg/dL
≥ 19 years 0.61-1.24 mg/dL 0.44-1.00 mg/dL



eGFR:
≥ 18 years > 60 mL/min/1.73 m2
< 18 years Not calculated (See Addtl. Info.)


1. Pediatric reference ranges adopted from "CLSI-based transference of the CALIPER database of pediatric reference intervals to Beckman Coulter DxC biochemical assays" Clinical Biochemistry 48 (2015) 870–880
2. Normal range for adults was adopted from vendor Chemistry Information Sheet and verified by running 53 female and 44 male lab volunteers at UCSF Clinical Labs.
Synonyms GFR; eGFR; glomerular filtration rate
Stability Room temperature 8 hours, refrigerated 2 days, frozen at -20C 1 week
Turn around times STAT 1 hour, Routine 4 hours
Additional information To convert mg/dL to µmol/L (SI units) multiply by 88.4.

Estimated GFR (eGFR) is reported with serum creatinine results in adults and is determined using the CKD-EPI equation (creatinine results traceable to isotope dilution mass spec IDMS calibration). Results greater than 120 mL/min/1.73 meters squared body surface area are displayed as > 120 mL/min and are not reported as an exact number. Note that the estimated GFR result is not reliable in certain groups including severely ill patients. Estimates of GFR with the CKD-EPI equation like other equations may also be less accurate in specific ethnic groups (eg, Asians in the United States), pregnant women, and those with unusual muscle mass, body habitus, and weight (eg, morbid obesity, amputees). Reference: Assessment of Kidney Function. WWW.UpToDate.com

CKD-EPI equation:

GFR = 141 x min (Scr /κ, 1)α x max(Scr /κ, 1)-1.209 x 0.993Age x 1.018 [if female] x .159 [if African-American]


where:
- Scr is serum creatinine in mg/dL,
- κ is 0.7 for females and 0.9 for males,
- α is -0.329 for females and -0.411 for males,
- min indicates the minimum of Scr /κ or 1, and
- max indicates the maximum of Scr /κ or 1.

According to the National Kidney Disease Education Program, the best equation for estimating glomerular filtration rate (GFR) from serum creatinine in children is the Bedside Isotope Dilution Mass Spectrometry (IDMS)-traceable Schwartz equation
http://www.nkdep.nih.gov/lab-evaluation/gfr-calculators/children-conventional-unit.shtml

Bedside IDMS-traceable Schwartz Equation for Children

GFR (mL/min/1.73 m2) = (0.41 x Height in cm) / Creatinine in mg/dL)
CPT coding 82565
LOINC code 2160-0
Last Updated 11/16/2016 8:22:37 AM
Entry Number 265
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