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Coxiella burnetii Antibodies, IgG & IgM
|Test group||Q fever|
|Container type||Gold top|
|Amount to Collect||2 mL blood|
|Preferred volume||1 mL serum|
|Min. Volume||0.2 mL serum
|Processing notes||Refrigerate serum. Order Quest # 4085N.|
|Normal range||Negative titer < 16|
|Synonyms||Q fever antibodies|
|Turn around times||Test run Tuesday and Friday. Turnaround time: 3-6 days.|
|Reflex?||If screen is positive the titers will be performed at an additional charge.|
|Additional information||This test includes both IgM and IgG antibodies to both phase I and II antigens and offers greater sensitivity than the formerly used CF test; the phase II IgG antibody corresponds most closely to the antibody detected in the latter.
The ratio of phase II to phase I antibodies is commonly > 1 in acute infection, is usually =1 in granulomatous hepatitis, and if < 1 suggests chronic infection such as endocarditis. Submit paired sera, one collected within 1 wk of onset of illness and another 2-3 weeks later; occasional patients will not show a rise in IgG phase II titer rise for 4-6 weeks, especially if antibiotic therapy has been given. IgM antibodies develop earlier and last a few weeks to a few months, whereas IgG antibodies may last for life. Although a single IgM titer of > 256 is highly suggestive of acute infection, diagnosis is most reliable when based on a titer increase of at least 4-fold. Testing a single serum is sufficient for periodic monitoring of employees by Employee Health.
|Last Updated||10/30/2014 10:57:12 AM|