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Lab Manual for Moffitt-Long and Mount Zion

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Coxiella burnetii Antibodies, IgG & IgM

Item Value
Approval req'd? No
Available Stat? No
Test code QFEV
Test group Q fever
Performed by Quest
Sendout? Yes
Method IFA
Container type Gold top
Amount to Collect 2 mL blood
Sample type Serum
Preferred volume 1 mL serum
Min. Volume 0.2 mL serum
Processing notes Refrigerate serum. Order Quest # 4085N.
Units Titer
Normal range Negative titer < 16
Synonyms Q fever antibodies
Turn around times Test run Tuesday and Friday. Turnaround time: 3-6 days.
Additional information This test includes both IgM and IgG antibodies to both phase I and II antigens and offers greater sensitivity than the formerly used CF test; the phase II IgG antibody corresponds most closely to the antibody detected in the latter.

The ratio of phase II to phase I antibodies is commonly > 1 in acute infection, is usually =1 in granulomatous hepatitis, and if < 1 suggests chronic infection such as endocarditis. Submit paired sera, one collected within 1 wk of onset of illness and another 2-3 weeks later; occasional patients will not show a rise in IgG phase II titer rise for 4-6 weeks, especially if antibiotic therapy has been given. IgM antibodies develop earlier and last a few weeks to a few months, whereas IgG antibodies may last for life. Although a single IgM titer of > 256 is highly suggestive of acute infection, diagnosis is most reliable when based on a titer increase of at least 4-fold. Testing a single serum is sufficient for periodic monitoring of employees by Employee Health.
LOINC code 22211-7
Last Updated 2/14/2013 11:51:25 AM
Entry Number 261
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