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Coxiella burnetii Antibodies, IgG & IgM
| Item | Value |
|---|---|
| Approval req'd? | No |
| Available Stat? | No |
| Test code | QFEV |
| Test group | Q fever |
| Performed by | Quest |
| Sendout? | Yes |
| Method | IFA |
| Container type | Gold top |
| Amount to Collect | 2 mL blood |
| Sample type | Serum |
| Preferred volume | 1 mL serum |
| Min. Volume | 0.2 mL serum |
| Processing notes | Refrigerate serum. Order Quest # 4085N. |
| Units | Titer |
| Normal range | Negative titer < 16 |
| Synonyms | Q fever antibodies |
| Turn around times | Test run Tuesday and Friday. Turnaround time: 3-6 days. |
| Additional information | This test includes both IgM and IgG antibodies to both phase I and II antigens and offers greater sensitivity than the formerly used CF test; the phase II IgG antibody corresponds most closely to the antibody detected in the latter. The ratio of phase II to phase I antibodies is commonly > 1 in acute infection, is usually =1 in granulomatous hepatitis, and if < 1 suggests chronic infection such as endocarditis. Submit paired sera, one collected within 1 wk of onset of illness and another 2-3 weeks later; occasional patients will not show a rise in IgG phase II titer rise for 4-6 weeks, especially if antibiotic therapy has been given. IgM antibodies develop earlier and last a few weeks to a few months, whereas IgG antibodies may last for life. Although a single IgM titer of > 256 is highly suggestive of acute infection, diagnosis is most reliable when based on a titer increase of at least 4-fold. Testing a single serum is sufficient for periodic monitoring of employees by Employee Health. |
| LOINC code | 22211-7 |
| Last Updated | 2/14/2013 11:51:25 AM |
| Entry Number | 261 |
If you have additional questions regarding this test, please call: 415-353-1667