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|Test Update Information||Method changed from Siemens Centaur XP platform to Abbott Architect i1000 platform on October 3, 2016. The Abbott Architect cortisol assay has less cross reactivity with synthetic and endogenous steroids than the previous Siemens Centaur assay and correlates better with mass spectrometry cortisol assays.|
|Performed by||China Basin Chemistry|
|In House Availability||Test available on day shift, 7 days per week.|
|Method||Chemiluminescent Microparticle Immunoassay (Abbott Architect i1000)|
|Collection Instructions||A morning sample is usually recommended.|
|Container type||Preferred: Gold top or Red top; Acceptable: Green Top (Sodium/Lithium Heparin)|
|Amount to Collect||1 mL blood|
|Preferred volume||0.5 mL serum|
|Min. Volume||0.2 mL serum|
|UCSF Rejection Criteria||Samples will not be rejected based on time of collection.|
|Normal range|| Adult Reference Range
Reference range adopted from vendor performed studies and verified by running lab personnel.
Pediatric Reference Range
Pediatric reference ranges adopted from CALIPER Pediatric Reference Interval study performed on random samples using the Abbott Architect i2000 assay. Morning samples gave results approximately 10% higher than afternoon samples.
Bailey et al. Clinical Chemistry 59:9 1393–1405 (2013)
|Synonyms||Compound F; 11-hydroxycorticosteroids; 11-hydroxycorticoids; 11-OH steroids; 11-OH corticosteroids; Cosyntropin provocative testing|
|Turn around times||1-3 days|
|Additional information|| The Architect cortisol assay is highly specific for cortisol and correlates well with mass spectrometry methods (Dodd AJ et al. Annals of Clinical Biochemistry 2014).
The specificity of the ARCHITECT Cortisol assay was determined by studying the cross-reactivity of compounds whose chemical structure or concurrent usage may potentially interfere with the ARCHITECT Cortisol assay. Specificity of the assay was determined by spiking each compound into human serum specimens with cortisol levels of 11.4 and 12.0 µg/dL. Cross reactivity results with other steroids are listed below.
|Last Updated||10/7/2016 1:14:18 PM|
|Lab Procedure Link||Click here for Procedure|