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Coccidioides immitis Antibody, Complement fixation
|Utilization Guidelines||The Complement fixation (CF) test for antibodies to Coccidioides should be ordered only in patients with a recent positive Immunodiffusion (ID) test.|
|Test group||Coccidioides immitis Antibody|
|Performed by||UC Davis Coccidiomycosis Laboratory|
|Container type||Gold top, CSF tube or sterile collection tube|
|Amount to Collect||4 mL blood or 2 mL CSF|
|Sample type||Serum or CSF|
|Preferred volume||2 mL serum or CSF|
|UCSF Rejection Criteria||Hemolyzed samples|
|Processing notes||Send out to UC Davis Coccidioidomycosis Serology Laboratory, School of Medicine, Room 3144 Tupper Hall, West Science Drive, University of California, Davis, CA 95616 (By Courier)|
|Turn around times||Test run twice per week. Results available in 3-7 days|
|Additional information||UCDCF Results reported as 4+, 3+, 2+, 1+, or 0 at a given serial dilution of the specimen.
4+ is significant (or 3+ provided the immunodiffusion is also positive). 2+ and 1+ are not significant. A rising titer is unfavorable. A titer of > 1:16 in the serum is often associated with metapulmonary dissemination, but a lower titer can be associated limited dissemination e.g., single osseous or cutaneous lesion of meningeal involvement.
Samples that are anticomplementary or hemolyzed cannot be assayed by this method; use the immunodiffusion assay instead. Rise in titer is significant and parallels severity. Test is relatively specific, but rare cross-reactions may occur with blastomyces or histoplasma infections. Low CSF titers may occasionally be present, in the absence of meningitis, due to passive spill-over from extremely high serum titers.
|Last Updated||11/21/2013 12:47:42 PM|