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|Method||Liquid Chromatography Tandem Mass Spectrometry|
|Collection Instructions||Do NOT use serum separator tube.
Optimum time to sample is 12-14 hours after oral dose.
|Container type||Red top (Gold top NOT acceptable)|
|Amount to Collect||6 mL blood|
|Preferred volume||3 mL serum|
|Min. Volume||1.5 mL serum|
|UCSF Rejection Criteria||Sample collected in Gold top|
|Processing notes||Separate and refrigerate serum as soon as possible.|
|Critical value||Quest Priority-1: ≥ 600 µg/L|
|Stability||Room temperature 1 hour, refrigerated 5 days, frozen at -20C 1 month.|
|Turn around times||Test run Wednesday. Turnaround time: 3-8 days.|
|Additional information||Includes desmethyl metabolite.
Neuroleptic drugs cause increased N-Desmethyl Clomipramine.
There is great variability of N-Desmethyl Clomipramine to Clomipramine ratio of approximately 2-6:1. The above ranges are a consensus of several publications. The distribution of individual patient concentrations is not normal. The most common side effects are dry mouth, somnolence, and tremor.
|Last Updated||10/28/2013 11:48:30 AM|