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Lab Manual for Moffitt-Long and Mount Zion

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Clomipramine

Item Value
Approval req'd? No
Available Stat? No
Test code CLMP
Performed by Quest
Sendout? Yes
Method Liquid Chromatography Tandem Mass Spectrometry
Collection Instructions Do NOT use serum separator tube.

Optimum time to sample is 12-14 hours after oral dose.
Container type Red top (Gold top NOT acceptable)
Amount to Collect 6 mL blood
Sample type Serum
Preferred volume 3 mL serum
Min. Volume 1.5 mL serum
UCSF Rejection Criteria Sample collected in Gold top
Processing notes Separate and refrigerate serum as soon as possible.
Units µg/L (mcg/L)
Normal range
Clomipramine 50-250 µg/L
DM-clomipramine 150-350 µg/L
Total 200-600 µg/L
Critical value Quest Priority-1: ≥ 600 µg/L
Synonyms Anafranil
Stability Room temperature 1 hour, refrigerated 5 days, frozen at -20C 1 month.
Turn around times Test run Wednesday. Turnaround time: 3-8 days.
Additional information Includes desmethyl metabolite.

Neuroleptic drugs cause increased N-Desmethyl Clomipramine.

There is great variability of N-Desmethyl Clomipramine to Clomipramine ratio of approximately 2-6:1. The above ranges are a consensus of several publications. The distribution of individual patient concentrations is not normal. The most common side effects are dry mouth, somnolence, and tremor.
CPT coding 83789-90
LOINC code 3491-8
Last Updated 10/28/2013 11:48:30 AM
Entry Number 218

If you have additional questions regarding this test, please call: 415-353-1667

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