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Chlamydia Antibody (MIF)
|Test code||CPNI (C. pneumoniae (TWAR)), CTRI (C. tranchomatis), CPSI (C. psittaci)|
|Performed by||Focus Diagnostics via Quest|
|Method||Micro-immunofluorescence assay (MIF)|
|Collection Instructions||Request MUST specify the single organism sought|
|Container type||Gold top or Red top|
|Amount to Collect||2 mL blood|
|Preferred volume||1 mL serum|
|Min. Volume||0.25 mL serum|
|Processing notes|| Refrigerate sample. Enter the appropriate test code for the organism requested:
|Synonyms||LGV; Parrot fever; Psittacosis; congenital infection; prenatal infection|
|Stability||Room temperature 1 week, refrigerated 2 weeks, frozen 1 month.|
|Turn around times||Test run 6x per week. Turnaround time 5-6 days.|
|Additional information||IgG, IgA and IgM antibody tests are performed for each organism requested
The immunofluorescent antibody test is more sensitive than CF and is the best serologic test for diagnosing chlamydial infection, although seroconversion may be delayed, as with the CF test. Due to the prolonged incubation period often seen in acute disease, the usual criterion for acute infection of a 4 fold rise in titer may not be demonstrable.
In patients infected with C. pneumoniae (TWAR), 70% of whom develop IF antibody (compared with 50% for CF) a single IgM titer > 32 or an IgG titer > 512 suggests acute infection.
Because antibody persists from prior exposures, levels (even of IgM) are often unhelpful in the diagnosis of urethritis or cervicitis in adults, although very high titers suggest invasive disease, e.g., salpingitis, epidydimitis or proctitis. Transplacental passage of maternal antibody may interfere with serodiagnosis of acute infection in infants.
|CPT coding||86632-90, 86631-90 x2 for each organism tested.|
|Last Updated||10/25/2013 12:18:42 PM|