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Daratumumab-Specific, Immunofixation

Item Value
Available Stat? No
Test code DARA
Performed by Quest
Sendout? Yes
Method Immunofixation
Collection Instructions Overnight fasting is preferred.
Container type Gold-top or Red-top tube
Amount to Collect 4
Sample type SER
Preferred volume 2
Min. Volume 1
Processing notes Aliquot on freeze serum. Send sample to CB frozen. Order Quest test code 94514.
Ref Lab Rejection Criteria Specimens other then serum
Normal range
Stability Room temperature: 5 days
Refrigerated: 6 days
Frozen: 6 months
Turn around times 4-6 days
Additional information Daratumumab is an anti-CD38 IgGk monoclonal antibody currently in clinical development for multiple myeloma (MM) treatment. In MM, malignant cells secrete high levels of monoclonal immunoglobulin (M-protein) that is commonly detectable by serum immunofixation electrophoresis (IFE). As immunoglobulin, daratumumab also can be detected in IFE and may co-migrate with M-protein in a subset of patients (~50% of MM patient produce IgGk M protein). Addition of anti-idiotypic antibodies raised against daratumumab to patient serum containing daratumumab alters banding pattern as assessed to IFE (daratumumab shift) by forming a Daratumumab and anti-Daratumumab complex, helping to distinguish between therapeutic monoclonal antibody and M-protein present in the serum.
CPT coding 86334
Last Updated 8/18/2017 2:38:55 PM
Entry Number 1805
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