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Statin Sensitivity SLCO1B1, 1 Variant

Item Value
Available Stat? No
Test code SCO1B1
Performed by ARUP
Sendout? Yes
Method Polymerase Chain Reaction/Fluorescence Monitoring
Container type Lavender top
Amount to Collect 3 mL
Sample type Whole blood
Preferred volume 3 mL
Min. Volume 1 mL
Processing notes Do not aliquot sample. Transport to CB refrigerated. Order ARUP test code 2008426.
Ref Lab Rejection Criteria Plasma or serum. Heparinized specimens.
Normal range
Stability Ambient: 72 hours; Refrigerated: 2 weeks; Frozen: 1 month
Turn around times 5-10 days
Additional information Simvastatin is a commonly prescribed hypolipidemic drug used for cholesterol reduction and control. Approximately 1-5 percent of exposed individuals may experience a dose-dependent myopathy (skeletal muscle toxicity). Symptoms may include pain, muscle weakness, and cramps. The organic anion transporter polypeptide 1B1, encoded by SLCO1B1, transports active simvastatin acid from the blood stream into the liver. This test detects a common variant that reduces the function of the transporter, resulting in an increased plasma concentration of the drug.
CPT coding 81400-90
Last Updated 11/29/2016 12:06:45 PM
Entry Number 1728
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