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Lipoprotein Metabolism Profile

Item Value
Available Stat? No
Test code LMPP
Performed by Mayo
Sendout? Yes
In House Availability No
Method Ultracentrifugation/Electrophoresis/Automated Enzymatic/Colorimetric Analysis
Patient Preparation 1. Fasting-overnight (12-14 hours)

2. Patient must not consume any alcohol for 24 hours before the specimen is drawn.
Container type Red-top or gold-top
Amount to Collect 10 mL (blood)
Sample type Serum
Preferred volume 5 mL (serum)
Min. Volume 2 mL (serum)
Processing notes Aliquot and refrigerate. Send to CB refrigerated. Order Mayo test code LMPP.
Ref Lab Rejection Criteria Gross Hemolysis/Icterus
Normal range
Stability Refrigerated 7 days
Frozen 60 days
Turn around times 4 - 7 days
Additional information Lipoprotein metabolism profile analysis adds practical information about the etiology of cholesterol and/or triglyceride elevation. In some patients, increased serum lipids reflects elevated levels of intermediate-density lipoprotein (IDL), very-low-density lipoprotein (VLDL), lipoprotein a (Lp[a]), or even the abnormal lipoprotein complex-LpX. These elevations can be indicative of a genetic deficiency in lipid metabolism or transport, nephrotic syndrome, endocrine dysfunction or even cholestasis. Identification of the lipoprotein associated with lipid elevation is achieved using the gold-standard methods, which include ultracentrifugation, selective precipitation, electrophoresis, and direct measurement of cholesterol and triglycerides in isolated lipoprotein fractions. Proper characterization of a patient's dyslipidemic phenotype aids clinical decisions and guides appropriate therapy.

Classifying the hyperlipoproteinemias into phenotypes places disorders that affect plasma lipid and lipoprotein concentrations into convenient groups for evaluation and treatment. A clear distinction must be made between primary (inherited) and secondary (liver disease, alcoholism, metabolic diseases) causes of dyslipoproteinemia. Lipoprotein profiling will identify the presence of Lp(a) and LpX and distinguish between the following dyslipidemias:

Exogenous hyperlipemia (Type I)

Familial Hypercholesterolemia (Type IIa)

Familial Combined Hyperlipidemia (Type IIb)

Familial dysbetalipoproteinemia (Type III)

Endogenous hyperlipemia (Type IV)

Mixed hyperlipemia (Type V)
CPT coding 82465-90, 84478-90, 82172-90, 83718-90, 83700-90
LOINC code
TCS Cholesterol, Total, CDC,S 2093-3
HDLS HDL Cholesterol, CDC, S 2085-9

TRIGC Triglycerides, CDC,S 2571-8
APLBS Apolipoprotein B, S 1884-6
2839 LDL Cholesterol 2089-1
2840 LDL Triglycerides 3046-0
2844 VLDL cholesterol 2091-7
2847 VLDL triglycerides 3047-8
2842 Beta VLDL Cholesterol 2091-7
2843 Beta VLDL triglycerides 3045-2
2855 Chylomicron cholesterol 34467-1
2856 Chylomicron triglycerides 35363-1
2849 Lp(a) Cholesterol 10835-7
23924 LpX 42178-4
23937 Interpretation 59462-2

Last Updated 5/31/2016 1:27:02 PM
Entry Number 1723
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