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Pro-B-Type Natriuretic Peptide, N-terminal (New test)

Item Value
Available Stat? No
Test code PBNP
Performed by Quest
Sendout? Yes
Method ECLIA
Container type Gold top, Red top or Lavender Top
Amount to Collect 2 mL blood
Sample type Serum or EDTA Plasma
Preferred volume 1 mL Serum or EDTA plasma
Min. Volume 0.3 mL Serum or EDTA plasma
UCSF Rejection Criteria Gross hemolysis
Processing notes Centrifuge and aliquot serum/plasma. Freeze aliquot. Transport to CB frozen. Order Quest test code 11188.
Ref Lab Rejection Criteria Gross hemolysis
Units pg/mL
Normal range
18-49 years ≤300 pg/mL Normal, heart failure unlikely
≥450 pg/mL High probability of heart failure
≥ 50 Years ≤300 pg/mL Normal, heart failure unlikely
≥900 pg/mL High probability of heart failure
Synonyms BNP; brain type; ANF; ANH; Atrial Natriuretic factor; Atrial Natriuretic Hormone; Pro-BNP; NT-Pro BNP
Stability Room temperature or refrigerated 3 days, frozen 1 year.
Turn around times 3-6 days
Additional information BNP, is the active form of this protein hormone, has a short biological half-life of 20 minutes. NT-ProBNP, inactive fragment, has a half-life of 1-2 hours. Both are increased in CHF and both levels correlate to the severity of condition. In the future these two hormones may be used as prognostic indicators in ACS also; studies have shown that levels predict cardiac mortality and adverse cardiac events in patients with ACS.

Because of its longer half-life, there are advantages to measuring NT-ProBNP over BNP. In CHF patients receiving exogenous and synthetic BNP for treatment, BNP levels may be affected while NT-ProBNP will not be affected. NT-ProBNP is thought to be primarily cleared by kidneys and therefore falsely elevated in severe renal disease.

Note that BNP is available stat while NT-Pro BNP is not
CPT coding 83880-90
LOINC code 33762-6
Last Updated 1/27/2016 10:00:55 AM
Entry Number 1705
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