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Mannose Binding Lectin

Item Value
Approval req'd? No
Available Stat? No
Test code MBL
Performed by Quest
Sendout? Yes
Method Enzyme Linked Immunosorbent Immunoassay (ELISA)
Patient Preparation Overnight fasting is preferred but not required
Container type Red top or Gold top
Amount to Collect 2 mL blood
Sample type Serum
Preferred volume 1 mL serum
Min. Volume 0.3 mL serum
UCSF Rejection Criteria Hemolyzed or lipemic samples
Processing notes Aliquot serum and freeze. Ship frozen to CB
Ref Lab Rejection Criteria Hemolyzed, lipemic or thawed samples
Units ng/mL
Normal range ≥ 100 ng/mL
Stability Room temperature 4 hours, refrigerated 4 hours, frozen 3 weeks.
Turn around times 7-10 days
Additional information Mannan-Binding Lectin (MBL) is considered an important component of the innate immune system. Clinical studies have used 50 or 100 ng/mL to define severe MBL deficiency. MBL is also known to activate the classical complement pathway through its binding to serine proteases MASP-2 and MASP-1. MBL deficiency has been associated with recurrent infections in children 6 months to 17 months of age, during the time when the adaptive immune system (IgG production) is not fully mature.

In conjunction with clinical findings and other laboratory tests, the deficiency of Mannose Binding Lectin (MBL) can be used to aid in the determination of susceptibility to infection.
CPT coding 83520-90
Last Updated 8/7/2014 9:50:36 AM
Entry Number 1525
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