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Mannose Binding Lectin (New test)
| Item | Value |
|---|---|
| Approval req'd? | No |
| Available Stat? | No |
| Test code | MBL |
| Performed by | Quest |
| Sendout? | Yes |
| Method | Enzyme Linked Immunosorbent Immunoassay (ELISA) |
| Patient Preparation | Overnight fasting is preferred but not required |
| Container type | Red top or Gold top |
| Amount to Collect | 2 mL blood |
| Sample type | Serum |
| Preferred volume | 1 mL serum |
| Min. Volume | 0.3 mL serum |
| UCSF Rejection Criteria | Hemolyzed or lipemic samples |
| Processing notes | Aliquot serum and freeze. Ship frozen to CB |
| Ref Lab Rejection Criteria | Hemolyzed, lipemic or thawed samples |
| Units | ng/mL |
| Normal range | ≥ 100 ng/mL |
| Stability | Room temperature 4 hours, refrigerated 4 hours, frozen 3 weeks. |
| Turn around times | 7-10 days |
| Additional information | Mannan-Binding Lectin (MBL) is considered an important component of the innate immune system. Clinical studies have used 50 or 100 ng/mL to define severe MBL deficiency. MBL is also known to activate the classical complement pathway through its binding to serine proteases MASP-2 and MASP-1. MBL deficiency has been associated with recurrent infections in children 6 months to 17 months of age, during the time when the adaptive immune system (IgG production) is not fully mature. In conjunction with clinical findings and other laboratory tests, the deficiency of Mannose Binding Lectin (MBL) can be used to aid in the determination of susceptibility to infection. |
| CPT coding | 83520-90 |
| Last Updated | 1/4/2013 9:02:27 AM |
| Entry Number | 1525 |
If you have additional questions regarding this test, please call: 415-353-1667