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C1 Esterase Inhibitor Deficiency panel
| Item | Value | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Approval req'd? | Yes, contact Immunology at x3-1712. C4 screening must be done first; if the C4 level is normal, this panel of tests will not be performed | ||||||||||||||||||||
| Available Stat? | No | ||||||||||||||||||||
| Test code | C1EI | ||||||||||||||||||||
| Performed by | Quest | ||||||||||||||||||||
| Sendout? | Yes | ||||||||||||||||||||
| Patient Preparation | An 8 hour fast before specimen collection is preferred | ||||||||||||||||||||
| Collection Instructions | Collect and allow to clot in ice slurry. Bring immediately to lab on ice. Note special sample requirements for B&T patients |
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| Container type | Red top on ice (Gold top unacceptable) Lavender top on ice for B&T patients |
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| Amount to Collect | 6 mL blood | ||||||||||||||||||||
| Sample type | Serum EDTA Plasma for B&T patients |
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| Preferred volume | 3 mL serum in 3 aliquots of 1 mL each | ||||||||||||||||||||
| Min. Volume | 0.5 mL serum each | ||||||||||||||||||||
| UCSF Rejection Criteria | Not delivered on ice. Sample collected in Gold top | ||||||||||||||||||||
| Processing notes | Centrifuge immediately under refrigeration. Freeze three separate aliquots at ≤ 60C in plastic tubes and ship on dry ice. Order Quest # 44768P, 298 and 44784P Note that LabCorp requires EDTA plasma for B&T patients. |
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| Units | see normal ranges | ||||||||||||||||||||
| Normal range | C1EI activity (by decay of C1r):
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| Synonyms | Angioedema Panel; C1-esterase inhibitor; angioneurotic edema; anti-C1r; C1r; C4DX/C4 ratio; HAE; HAN E; Hereditary angioneurotic edema | ||||||||||||||||||||
| Turn around times | Test performed Tuesday and Thursday. Turnaround time: 3-8 days. | ||||||||||||||||||||
| Additional information | Includes C1EI activity, C1EI qauntitation and C1q quantitation. The results expected of these assays in the different clinical settings in which low C4 levels are seen are:
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| LOINC code | 4477-6 | ||||||||||||||||||||
| Last Updated | 12/19/2012 4:29:09 PM | ||||||||||||||||||||
| Entry Number | 149 |
If you have additional questions regarding this test, please call: 415-353-1667