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|Performed by||Molecular Diagnostics|
|In House Availability||Run 1-2 times per week as needed|
|Method||Fluorescent in-situ hybridization (FISH)|
|Collection Instructions||For UCSF Samples (from remote sites) Click here for sample collection instructions
For NON-UCSF Samples Click here for Requisition form & Account set-up instructions. Note we only do institutional billing.
|Sample type||Formalin-fixed, paraffin-embedded tissue on three (3) unstained slides (5 microns thick) on charged glass. One adjacent hematoxylin and eosin stained (H&E) slide should also be included. Slides should be labeled with pathology case number and block identification.|
|Preferred volume||3 unstained slides|
|Min. Volume||1 unstained slides|
|UCSF Rejection Criteria||All required slides not included. Insufficient tumor present on slide as determined by pathologist. Slides not labeled or not accompanied by completed requisition form.|
|Stability||Slides are stable indefinitely at room temperature|
|Turn around times||10-14 days|
|Additional information||An interpretation of this test by a laboratory physician will automatically be performed and billed for separately.
EWSR1 gene rearrangement testing by FISH is designed to detect the translocations of EWSR1 gene in sarcomas. This feature is seen in Ewing sarcoma/peripheral neuroectodermal tumor (EWS/PNET).
The clinical interpretation of this test should be evaluated within the context of the patient's medical history, other diagnostic tests, and the histologic and immunohistochemical features of the tumor.
The test was validated by UCSF Clinical Laboratories to confirm performance characteristics, in compliance with current guidelines for clinical implementation.
|CPT coding||88368 x2|
|LDT or Mod FDA?||Yes|
|Last Updated||9/10/2013 8:55:53 AM|
If you have additional questions regarding this test, please call: 415-353-1667